Construction of Reverse Genetics System for Feline Calicivirus FCV‐BJ616 and Proteomic Analysis
MicrobiologyOpen, Volume 15, Issue 1, February 2026.This study successfully isolated the FCV‐BJ616 strain derived from cats and established a reverse genetics system. In vivo experiments showed that rFCV‐BJ616 exhibits wild‐type virulence, leading to high fever, weight loss, and multi‐organ lesions in infected cats. Proteomic analysis indicated that both rFCV‐BJ616 and FCV‐BJ616 share similar regulatory
Chunmei Xu +9 more
wiley +1 more source
MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
RNA Helicase DDX3 Interacts with the Capsid Protein of Hepatitis E Virus and Plays a Vital Role in the Viral Replication [PDF]
Shaoli Lin +6 more
openalex +1 more source
Modeling Obesity and Weight Loss in Mice Using Novel AAV Approaches
Obesity, Volume 34, Issue 2, Page 417-427, February 2026.ABSTRACT Objective This study utilized AAV gene delivery as an approach to induce and reverse hyperphagia in mice. We hypothesized that the delivery of orexigenic neuropeptides to the brain via AAV precipitates obesity and that the implementation of genetic switches to reverse transgene expression would elicit weight loss.
Hunter G. Sellers +12 more
wiley +1 more source
Immunoinformatics approach for design novel multi-epitope prophylactic and therapeutic vaccine based on capsid proteins L1 and L2 and oncoproteins E6 and E7 of human papillomavirus 16 and human papillomavirus 18 against cervical cancer. [PDF]
Osong Public Health Res PerspectRyan N +5 more
europepmc +1 more source
Protease‐mediated maturation of M‐PMV reverse transcriptase into a functional heterodimer
Protein Science, Volume 35, Issue 2, February 2026.Abstract Reverse transcriptase (RT) of retroviruses orchestrates viral replication, yet its structural diversity remains poorly understood. Well‐studied RTs, such as those from HIV‐1, murine leukemia virus, and avian myeloblastosis virus, were characterized decades ago, but less prominent retroviruses have escaped detailed analysis.
Marina Kapisheva +6 more
wiley +1 more source
Novel Wide‐Spectrum Virucidal Lipid Nanoparticles
Small, Volume 22, Issue 7, 2 February 2026.POSTAN is a novel broad‐spectrum antiviral nanoparticle that combines safety with potent virucidal activity. Composed of biocompatible lipids, it mimics heparan sulfate proteoglycans and lipid rafts exploited by viruses, thereby dismantling viral envelopes and blocking replication.
Yugo Araújo Martins +10 more
wiley +1 more source
Bacterial Expression of Gene‐Encoding DNA Origami Structures
Small Structures, Volume 7, Issue 2, February 2026.Bacterial targeting via programmable DNA origami, varying in rigidity and compactness is unexplored. In transformation assays, origami reduces transformation efficiency compared to single‐stranded scaffolds. Structural features and surface modifications, however, improve transformation outcomes.
Verena Dobretzberger +7 more
wiley +1 more source
Detention of HPV L1 Capsid Protein and hTERC Gene in Screening of Cervical Cancer
, 2013 Bin Huang +7 more
openalex +1 more source