Results 51 to 60 of about 18,788,717 (252)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
On Stability Analysis of Car-Following Models with Various Discrete Operators
Applied SciencesThis paper investigates a car-following model that incorporates both classical and fractional discrete operators. While classical models have been extensively studied, the influence of discrete fractional operators on the stability of such systems has ...
Katarzyna Topolewicz, Ewa Girejko
doaj +1 more source
Analysis of Information Reliability on Dynamics of Connected Vehicles
IEEE Access, 2019 The emergence of connected and automated vehicles technology is beneficial in the enhancement of traffic flow performance, in particular, traffic stream stability and roadway capacity.
Tao Wang, Jing Zhang, Shubin Li
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Physical enhanced residual learning (PERL) framework for vehicle trajectory prediction
Communications in Transportation ResearchWhile physics models for predicting system states can reveal fundamental insights owing to their parsimonious structure, they may not always yield the most accurate predictions, particularly for complex systems.
Keke Long +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
, 2018 The scripts provided in this dataset are used to process and analyse the data from the SAE-L2 platoontest day. They are part of the performed analysis in the report: "Representing the Car-Following Behaviour of Adaptive Cruise Control (ACC) Systems Using
Blauw, M.H. (Mathieu)
core +1 more source