Results 61 to 70 of about 157,141 (260)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Analysis of Information Reliability on Dynamics of Connected Vehicles
IEEE Access, 2019 The emergence of connected and automated vehicles technology is beneficial in the enhancement of traffic flow performance, in particular, traffic stream stability and roadway capacity.
Tao Wang, Jing Zhang, Shubin Li
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
On Stability Analysis of Car-Following Models with Various Discrete Operators
Applied SciencesThis paper investigates a car-following model that incorporates both classical and fractional discrete operators. While classical models have been extensively studied, the influence of discrete fractional operators on the stability of such systems has ...
Katarzyna Topolewicz, Ewa Girejko
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
An Attention-Based Car-Following Model Based on Fused Data
IEEE Access, 2023 Data-driven car-following models provide an alternative approach to explore the underlying and complex driving behavior, while they suffer from poor generalization ability that makes it difficult to be applied to traffic simulations.
Li-Zheng Wang +5 more
doaj +1 more source
A behavioral microeconomic foundation for car-following models
Transportation Research Part C: Emerging Technologies, 2019 Abstract The objective of this paper is to develop a micro-economic modeling approach for car-following behaviors that may capture different risk-taking tendencies when dealing with different traffic conditions. The proposed framework allows for the consideration of perception subjectivity and judgement errors that may lead to unsafe acceleration ...
Samer H. Hamdar +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Physical enhanced residual learning (PERL) framework for vehicle trajectory prediction
Communications in Transportation ResearchWhile physics models for predicting system states can reveal fundamental insights owing to their parsimonious structure, they may not always yield the most accurate predictions, particularly for complex systems.
Keke Long +5 more
doaj +1 more source