Results 41 to 50 of about 404,164 (301)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu   +8 more
wiley   +1 more source

Модель транспортного потока, основанная на взаимодействии частиц с потенциалом действия

open access: yesVestnik KRAUNC: Fiziko-Matematičeskie Nauki, 2022
Современное бурное развитие беспилотных автомобилей ставит вопрос оценки последствия их внедрения на транспортный поток, что делает актуальной задачу создания смешанной модели. Объектом исследования статьи является транспортный поток.
Бобровская, О.П.   +2 more
doaj   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro   +11 more
wiley   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta   +6 more
wiley   +1 more source

A vehicle type-based approach to model car following behaviors in simulation programs (case study: Car-motorcycle following behavior)

open access: yesIATSS Research, 2019
Traffic simulation models often neglect the important role of motorcycles and assume a flow of various combinations of cars. This paper addresses how much different would be the behavior of a car driver while following a motorcyclist compared to cases in
Ehsan Amini   +3 more
doaj   +1 more source

Investigating the Impact of Connected and Automated Vehicles on Signalized and Unsignalized Intersections Safety in Mixed Traffic

open access: yesFuture Transportation, 2022
Road traffic crashes are a major safety problem, with one of the leading factors in crashes being human error. Automated and connected vehicles (CAVs) that are equipped with Advanced Driver Assistance Systems (ADAS) are expected to reduce human error. In
Amirhosein Karbasi, Steve O’Hern
doaj   +1 more source

Instabilities in car following and multi-anticipative car following models

open access: yesNonlinear Dynamics
Abstract Microscopic models of traffic depend on how the dynamics of one vehicle following another is considered. Such models play a key role in design, optimisation, performance and control of transportation networks. Based on how these models are constructed, instabilities in traffic are observed, which may be observed in real life ...
Ranganatha Belagumba Ramachandra   +2 more
openaire   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Solitons and kinks in a general car-following model [PDF]

open access: yesPhysical Review E, 2013
We study a car-following model of traffic flow which assumes only that a car's acceleration depends on its own speed, the headway ahead of it, and the rate of change of headway, with only minimal assumptions about the functional form of that dependence.
openaire   +3 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

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