Results 51 to 60 of about 404,164 (301)

A new car-following model considering acceleration of lead vehicle

open access: yesTransport, 2016
For decades, the general motors (gm) car following model has received a great deal of attention and provided a basic framework to describe the interactions between vehicles on the road.
Bingrong Sun   +4 more
doaj   +1 more source

CFD Investigation of the Effect of the Salient Flow Features in the Wake of a Generic Open-Wheel Race Car [PDF]

open access: yes, 2015
It is well known that in motorsport the wake from an upstream vehicle can be detrimental to the handling characteristics of a following vehicle, in particular in formulae with high levels of downforce.
Newbon, Joshua   +2 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Stability of heterogeneous linear and nonlinear car-following models

open access: yesFranklin Open
Stop-and-go waves in congested road traffic are complex collective phenomena with significant implications for traffic engineering, road safety and the environment.
Matthias Ehrhardt, Antoine Tordeux
doaj   +1 more source

A Reinforcement Learning Framework for Video Frame-Based Autonomous Car-Following

open access: yesIEEE Open Journal of Intelligent Transportation Systems, 2021
Car-following theory has received considerable attention as a core component of Intelligent Transportation Systems. However, its application to the emerging autonomous vehicles (AVs) remains an unexplored research area.
Mehdi Masmoudi   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

A Study on an Anthropomorphic Car-Following Strategy Framework of the Autonomous Coach in Mixed Traffic Flow

open access: yesIEEE Access, 2020
In this study, to explore the demand characteristics of autonomous coaches in mixed traffic flow, two sections of an expressway were selected for vehicle experiments.
Chen Zhao   +3 more
doaj   +1 more source

A merging model for motorway traffic [PDF]

open access: yes, 2006
Motorway merging has long been regarded as a major source of conflicts and congestion on motorways. Traditional studies of merging behaviour are based on gap acceptance models developed mainly for urban intersections, which tend to oversimplify the very ...
Wang, Jiao
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

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