Results 61 to 70 of about 11,974,013 (294)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A Reinforcement Learning Framework for Video Frame-Based Autonomous Car-Following

IEEE Open Journal of Intelligent Transportation Systems, 2021
Car-following theory has received considerable attention as a core component of Intelligent Transportation Systems. However, its application to the emerging autonomous vehicles (AVs) remains an unexplored research area.
Mehdi Masmoudi, Hamdi Friji, Hakim Ghazzai, Yehia Massoud   +3 more
doaj   +1 more source

Subcritical Hopf bifurcations in a car-following model with reaction-time delay [PDF]

, 2005
A nonlinear car-following model of highway traffic is considered, which includes the reaction-time delay of drivers. Linear stability analysis shows that the uniform flow equilibrium of the system loses its stability via Hopf bifurcations and thus ...
Orosz, G, Stepan, G
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Developing Artificial Intelligence-Based Car-Following Models Using Improved Permutation Entropy Analysis Results

Applied Sciences
Vehicle trajectories are time series, and entropy is a powerful tool for testing or quantifying the complexity of a given series. Entropy tools are often applied to variables such as velocity, acceleration, space headway, and time headway, but the local ...
Ali Muhssin Shahatha, İsmail Şahin
doaj   +1 more source

A behavioral microeconomic foundation for car-following models

Transportation Research Part C: Emerging Technologies, 2019
Abstract The objective of this paper is to develop a micro-economic modeling approach for car-following behaviors that may capture different risk-taking tendencies when dealing with different traffic conditions. The proposed framework allows for the consideration of perception subjectivity and judgement errors that may lead to unsafe acceleration ...
Samer H. Hamdar, Vinayak V. Dixit, Alireza Talebpour, Martin Treiber   +3 more
openaire   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Modeling Car-Following Behaviour of Turning Movements at Intersections with Consideration of Turning Radius

Journal of Advanced Transportation, 2020
In order to deeply analyze and describe the characteristics of car-following behaviour of turning vehicles at intersections, the features and application conditions of classic car-following models were analyzed firstly.
Fulu Wei, Yongqing Guo, Pan Liu, Zhenggan Cai, Qingyin Li, Long Chen   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Forwarding Collision Assessment with the Localization Information Using the Machine Learning Method

Journal of Advanced Transportation, 2022
Freeway crashes occupied 30% of total crashes. The advanced driver-assistance system (ADAS) often underestimates or omits the necessary collision warning.
Lei Guo, Yizhen Jia, Xianghui Hu, Feihong Dong   +3 more
doaj   +1 more source