Results 71 to 80 of about 404,164 (301)

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

open access: yesFEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa   +2 more
wiley   +1 more source

Revisit of Microscopic Car Following Models: Conventional and Machine Learning Perspectives [PDF]

open access: yes, 2021
University of Technology Sydney. Faculty of Engineering and Information Technology.Microscopic car following models, or simply car following models, are used to determine how vehicles are following one another on roadways.
Yu, Yang
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Performance of car following behaviour in microscopic traffic flow models

open access: yes, 2004
Microscopic simulation models are becoming increasingly important tools in modelling transport systems. They are applied in simulation programs for transport planning, traffic forecasting and advanced vehicle control and safety systems (AVCSS).
Brockfeld, Elmar   +2 more
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

On the calibration of stochastic car following models

open access: yes, 2023
Recent experimental and empirical observations have demonstrated that stochasticity plays a critical role in car following (CF) dynamics. To reproduce the observations, quite a few stochastic CF models have been proposed. However, while calibrating the deterministic CF models is well investigated, studies on how to calibrate the stochastic models are ...
Zhou, Shirui   +4 more
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

Piecewise linear car-following modeling [PDF]

open access: yesTransportation Research Part C: Emerging Technologies, 2012
19 pages, 3 ...
openaire   +3 more sources

Calibration and Validation of Microscopic Traffic Flow Models

open access: yes, 2004
Microscopic simulation models are becoming increasingly important tools in modeling transport systems. There are a large number of available models used in many countries.
Brockfeld, Elmar   +2 more
core  

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