Results 161 to 170 of about 142,846 (219)

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

Construction and Functional Evaluation of Cyclic Peptide-Based CAR T Cells in Tumor Models. [PDF]

Bio Protoc
Meng X, Wu Q, Tsai YH.
europepmc   +1 more source

Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota

Advanced Science, EarlyView.
Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal, Ronald Garcia, Guangyi Chen, Chantal D. Bader, Peter Sullivan, Alexander Popoff, Daniel Krug, Maja Hunter, Sebastian Walesch, Emilia Oueis, Christine Frank, Haowen Zhao, Joachim J. Hug, Sebastian Keller, Pascal Hirsch, Azat Tagirdzhanov, Tatiana Malygina, Mary Victory E. Gutierrez, Alexey Gurevich, Judith Boldt, Boyke Bunk, Jörg Overmann, Ulrich Nübel, Andreas Keller, Olga V. Kalinina, Rolf Müller   +25 more
wiley   +1 more source

Reversible control of CAR T cells through PROTAC compound targeting bromodomain mutant. [PDF]

Mol Ther Oncol
Kim Y, Lee DY, Choi JU, Jeun M, Lee HK, Choi SU, Park CH.   +6 more
europepmc   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

AI-driven discovery of GPNMB CAR T cells as a multi-cancer therapy. [PDF]

Cell
Baker DJ, Frommer LM, Uslu U, Patel KK, Zhu D, Engel NW, George JM, Zhao W, Kim SI, Sun L, Roselle C, Rommel PC, Young RM, Epstein JA, Hayat S, Arany Z, June CH.   +16 more
europepmc   +1 more source

Geometry‐Encoded Actuation as a Structural Interaction Layer in Origami Robots

Advanced Science, EarlyView.
We present geometry‐encoded actuation (GEA), a design framework that integrates multistable origami with liquid crystal elastomer actuators to encode environmental interactions into autonomous structural responses. GEA enables programmable shape transformation without continuous sensing or complex control, achieving robust adaptive manipulation and ...
Jianshu Zhou, Yitong Li, Junda Huang, Ian Zhang, Haoran Liu, Boyuan Liang, Yiyuan Zhang, Xiaohui Xiao, Qiguang He   +8 more
wiley   +1 more source

Endogenous CD28 Drives the Persistent Activity of CAR T Cells in Myeloma and Lymphoma Models. [PDF]

Blood Cancer Discov
Lieberman MM, Tong JH, Odukwe NU, Chavel CA, Bishara GG, Crasti KM, Herr MM, Goala P, Purdon TJ, Burchett R, Gillard BM, Brackett CM, Tario JD, Rosario SR, McGray AJR, Bramson JL, Davila ML, Brentjens RJ, Malek E, Lee KP, Olejniczak SH.   +20 more
europepmc   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

CD28-ICOS costimulation enhances the therapeutic efficacy of L1CAM-targeted CAR-T cells against ovarian and gastric cancers. [PDF]

J Immunother Cancer
Che X, Yun UJ, Lee J, Koh HH, Lee JY, Jeon J, So S, Kim Y, Chae JA, Zhang X, Kim H, Hwang J, Park E, Nam EJ, Kim GM, Jung M.   +15 more
europepmc   +1 more source