Results 171 to 180 of about 142,846 (219)

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

KLF4 overexpression in CAR T cells enhances antitumor potency by preventing exhaustion. [PDF]

J Immunother Cancer
Wang H, Meng X, Feng Y, Su A, Qin W, Shen J, Lu K, Gu L, Ma Y, Wang Y, Mao Y, Ji D, Zong L, Zheng M, Du Y, Cong J, Li J, Wang X.   +17 more
europepmc   +1 more source

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

Advanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song, Peilin Han, Jiaming Li, Xiaolong Li, Xiang Zhang, Jing Fan, Dongliang Liu, Jianfa Cai, Lingchao Zhang, Jun Wu   +9 more
wiley   +1 more source

Anti-CD19 CAR T Cells in Autoimmune Encephalitis: Inflammation Controlled, Neurodegeneration Unchecked? [PDF]

Ann Clin Transl Neurol
Mougiakakos D, Al-Dubai M, Walther D, Borie D, Lünemann JD, Pawlitzki M, Meuth SG, Henneicke S, Vielhaber S, Schreiber S.   +9 more
europepmc   +1 more source

Lithium‐Ion Battery Safety Evaluation by Quantifying Lithium Plating Degree Based on Pressure Signals

Advanced Science, EarlyView.
Low N/P cells enable controllable lithium plating, allowing the lithium plating degree (DLi) to be quantified and linked to thermal safety. Pressure signals during calibration provide a non‐destructive route to diagnose DLi, while thermal response tests define safety levels and management strategies. The framework remains applicable in commercial 12 Ah
Haonan Liu, Jiangong Zhu, Wenyuan Weng, Bin Shen, Wenjun Fan, Yang Wang, Huapeng Lu, Wuliyasu He, Chunjing Lin, Xuezhe Wei, Haifeng Dai   +10 more
wiley   +1 more source

Engineering CAR-T cells for solid tumors: Overcoming the microenvironment through integrated design and clinical translation. [PDF]

Oncoscience
Onyekweli SO, Omoruyi GO, Akintayo CO, Olaniyi SK.   +3 more
europepmc   +1 more source

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

A targeting lentiviral vector for generation of CAR-T cells in vivo. [PDF]

Sci Rep
Tuerxunyiming M, Yin JM, Zhu P, Liu M, Fu Z, Zhao Q.   +5 more
europepmc   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Humanized biparatopic nanobody-based CAR-T cells overcome antigen-heterogeneity in multiple myeloma. [PDF]

J Transl Med
Zhou J, Wu K, Lei B, Luo X, Shi F, Zhang Y, Kong X, Wang H, Zhou J, Guo H, He X.   +10 more
europepmc   +1 more source