Results 251 to 260 of about 614,006 (307)

NR2F6-modified CAR T cells drive extrinsic immunogenic cell death and antigen-agnostic immunity in solid tumors. [PDF]

Mol Ther Oncol
Klepsch V, Wolf D, Baier G.
europepmc   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Ten-year experience of CD22 CAR T cells for children and young adults with B-cell acute lymphoblastic leukemia. [PDF]

Blood Adv
Dreyzin A, Yates B, Shalabi H, Silbert SK, Wang HW, Yuan CM, Hoang CN, Culbert AA, Gava F, Nair MS, Giordani VM, Little L, Foley T, Nussenblatt V, Fry TJ, Stroncek DF, Highfill SL, Shah NN.   +17 more
europepmc   +1 more source

Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface

Advanced Science, EarlyView.
Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley   +1 more source

Ibrutinib exposure correlates with improved efficacy of CAR T cells in patients with mantle cell lymphoma. [PDF]

Blood Adv
Darnell EP, Gallagher KME, Kanska J, Scarfò I, Balderrama-Gutierrez G, Berger TR, Budka J, Bozym DJ, Huang T, Shen R, Leick MB, Maus MV.   +11 more
europepmc   +1 more source

CAR Intrinsic Design Pre-Shapes Transcriptional and Metabolic Networks in CAR T Cells. [PDF]

Metabolites
Agac Cobanoglu D, Franklin S, Hu Y, Boland DJ, Song X.   +4 more
europepmc   +1 more source

Tuning CAR-T cells by targeting cancer-associated glycan in pancreatic cancer. [PDF]

Nat Commun
Park S, Ho CE, Darnell EP, Wolff AN, Takei H, Birocchi F, Bouffard AA, Salas-Benito D, Escobar G, Leick MB, Mucci A, Berger TR, Maus MV.   +12 more
europepmc   +1 more source

B7-H3 nanobody-based CAR T cells control multiple myeloma growth, while dual BCMA/B7-H3 CAR T cells overcome antigen escape. [PDF]

J Hematol Oncol
Van der Vreken A, Meeus F, Tu C, van den Broecke L, Raimondi V, Vescovini R, Hanssens H, Watté F, Autaers D, Aragon MM, Billiau J, De Veirman K, Vanderkerken K, De Vlaeminck Y, Franceschini L, Lee H, Neri P, De Bruyne E, Storti P, Giuliani N, Breckpot K, Menu E.   +21 more
europepmc   +1 more source

Engineered nanovesicles as a DC vaccine to enhance the antitumor efficacy of CAR-T cells against solid tumors. [PDF]

J Nanobiotechnology
Ju S, Zhu T, Chen S, Wu Y, Huang X.
europepmc   +1 more source