Results 41 to 50 of about 5,909,290 (265)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Incorporating risk taking and driver errors in car-following models [PDF]

, 2016
This thesis investigated the effect of human factors on car-following behavior and developed a novel methodology to incorporate those in car-following models.
Saifuzzaman, Mohammad
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Subcritical Hopf bifurcations in a car-following model with reaction-time delay [PDF]

, 2005
A nonlinear car-following model of highway traffic is considered, which includes the reaction-time delay of drivers. Linear stability analysis shows that the uniform flow equilibrium of the system loses its stability via Hopf bifurcations and thus ...
Orosz, G, Stepan, G
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

On the Car-Following Theory

Promet (Zagreb), 2012
The article deals with bumper-to-bumper driving. A .systemicapproach to car-following (bumper-to-bumper driving)i.s described and the mathematical model has been developedand solved.
Janez Usenik, Milan Batista
doaj   +1 more source

High-Accuracy, High-Efficiency, and Comfortable Car-Following Strategy Based on TD3 for Wide-to-Narrow Road Sections

World Electric Vehicle Journal, 2023
To address traffic congestion in urban expressways during the transition from wide to narrow sections, this study proposed a car-following strategy based on deep reinforcement learning.
Pinpin Qin, Fumao Wu, Shenglin Bin, Xing Li, Fuming Ya   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Does Deep Learning Architectures Model Human‐Like Intelligent Response in Asymmetric Car‐Following Behaviour? A Novel Framework for Learning Acceleration–Deceleration Decisions

IET Intelligent Transport Systems
Accurate modelling of acceleration and deceleration decisions is vital for replicating car‐following behaviour, as these govern longitudinal control, traffic stability, and safety.
Nazmul Haque, Md Asif Raihan, Farhana Mozumder Lima, Md. Hadiuzzaman   +3 more
doaj   +1 more source

Calibrating Car-Following Models Using SUMO-in-the-Loop and Vehicle Trajectories From Roadside Radar

SUMO Conference Proceedings
This paper presents an innovative calibration method for car-following (CF) models in the Simulation of Urban MObility (SUMO) using real-world trajectory data from a 1.5 km signalized urban corridor, captured by roadside radars.
Maxwell Schrader, Arya Karnik, Alexander Hainen, Joshua Bittle   +3 more
doaj   +1 more source