Results 51 to 60 of about 2,687 (216)

An Improved Car-Following Model considering Desired Safety Distance and Heterogeneity of Driver’s Sensitivity

open access: yesJournal of Advanced Transportation, 2021
We investigate the dynamic performance of traffic flow using a modified optimal velocity car-following model. In the car-following scenarios, the following vehicle must continuously adjust the following distance to the preceding vehicle in real time.
Lei Zhang   +4 more
doaj   +1 more source

Development of kinks in car-following models [PDF]

open access: yesPhysical Review E, 2017
Many car-following models of traffic flow admit the possibility of absolute stability, a situation in which uniform traffic flow at any spacing is linearly stable. Near the threshold of absolute stability, these models can often be reduced to a modified Korteweg-deVries (mKdV) equation plus small corrections.
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

An Extended Car-Following Model at Signalised Intersections

open access: yesJournal of Advanced Transportation, 2018
An extended car-following model is proposed on the basis of experimental analysis to improve the performance of the traditional car-following model and simulate a microscopic car-following behaviour at signalised intersections.
Hongxing Zhao, Ruichun He, Changxi Ma
doaj   +1 more source

Research on car-following model based on molecular dynamics

open access: yesAdvances in Mechanical Engineering, 2021
The car-following model has always been a research hot spot in the field of traffic flow theory. Modeling the car-following behavior can quantify the longitudinal interaction between cars, thereby understanding the characteristics of traffic flow, and ...
Yanfeng Jia   +4 more
doaj   +1 more source

Early‐Phase Research in Pediatric Neuro‐Oncology

open access: yes
Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Modeling Car-Following Behaviour of Turning Movements at Intersections with Consideration of Turning Radius

open access: yesJournal of Advanced Transportation, 2020
In order to deeply analyze and describe the characteristics of car-following behaviour of turning vehicles at intersections, the features and application conditions of classic car-following models were analyzed firstly.
Fulu Wei   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

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