Results 71 to 80 of about 2,687 (216)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

A review on following behavioral models: Regular to connected autonomous vehicle heterogeneity

IATSS Research
Following behavior, an integral part of driving, is vital in describing the longitudinal interaction among vehicles. The traffic composition of the stream influences the following behavior.
Nazmul Haque, Md Asif Raihan, Md Mizanur Rahman, Md Hadiuzzaman   +3 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Fusion Modeling Method of Car-Following Characteristics

IEEE Access, 2019
Car-following model is indispensable to evaluate the characteristics of car-following behaviors. Through an analysis and comparison of data-driven and theoretically driven car-following models, it shows that the data-driven model has poor ...
Yufang Li, Xiaoding Lu, Chen Ren, Hongwei Zhao   +3 more
doaj   +1 more source

Modeling for Micro Traffic Flow with the Consideration of Lateral Vehicle’s Influence

Journal of Advanced Transportation, 2020
In order to make the car-following model describe the driving behavior of vehicle on urban road more accurately, existing car-following models are simulated using measured traffic data. According to the analysis of the simulation result, two new improved
Da-wei Liu, Zhong-ke Shi, Wen-Huan Ai
doaj   +1 more source

Car-Following Models: A Multidisciplinary Review

IEEE Transactions on Intelligent Vehicles
Car-following (CF) algorithms are crucial components of traffic simulations and have been integrated into many production vehicles equipped with Advanced Driving Assistance Systems (ADAS). Insights from the model of car-following behavior help us understand the causes of various macro phenomena that arise from interactions between pairs of vehicles ...
Zhang, Tianya, D., Ph., Jin, Peter J., D., Ph., McQuade, Sean T., D., Ph., Bayen, Alexandre, D., Ph., Piccoli, Benedetto   +8 more
openaire   +2 more sources

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

A vehicle type-based approach to model car following behaviors in simulation programs (case study: Car-motorcycle following behavior)

IATSS Research, 2019
Traffic simulation models often neglect the important role of motorcycles and assume a flow of various combinations of cars. This paper addresses how much different would be the behavior of a car driver while following a motorcyclist compared to cases in
Ehsan Amini, Masuod Tabibi, Ehsan Ramezani Khansari, Mohammadreza Abhari   +3 more
doaj   +1 more source