Results 241 to 250 of about 21,080,479 (286)

Cryo‐EM Analysis of Adenovirus Vector Reveals Purification Conditions Leading to Loss of Viral Fiber Proteins and Reduced Infectivity

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Vaccines and gene therapies require efficient delivery of genetic material to host cells. Viral vectors leverage viruses' ability to enter host cells to achieve this. Following the SARS‐CoV‐2 vaccine and novel gene therapies that utilize adenovirus vectors, there has been an increase in the demand for large‐scale production of vectors.
Betsy Widdicombe, Joseph D. Barritt, Nichakorn Pipatpadungsin, Braulio Carrillo Sanchez, Dale Stibbs, Lisa Cooper, Sarah L. Rouse, Daniel G. Bracewell   +7 more
wiley   +1 more source

Advances in CAR-T Cell Therapy: From Structural Design Innovations to Clinical Translation Challenges. [PDF]

J Cancer
Gao H, Fang Y, Zhang P, Qian Q.
europepmc   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Challenges and advances in CAR-T cell therapy for B-ALL. [PDF]

Biomark Res
Zha C, Wang Y.
europepmc   +1 more source

CAR T cell therapy beyond cancer: current status, challenges and future prospects. [PDF]

Signal Transduct Target Ther
Upadhyay S, Cho S, Upmanyu K, Gabr MT.
europepmc   +1 more source

Endotheliopathy in CAR T-Cell Therapy: Mechanistic Insights into the VWF/ADAMTS13 Axis and the Angiopoietin-Tie2 Pathway. [PDF]

TH Open
de Bruijn S, Vangenechten I, Anguille S, Gadisseur A.   +3 more
europepmc   +1 more source

Nursing insights into CAR T-cell therapy for systemic lupus erythematosus: Highlights of a standardized nursing system for CAR T-cell therapy. [PDF]

Rheumatol Immunol Res
Yang Y, Gao L, Wang K, Li X.
europepmc   +1 more source

Mechanism-resolving development of solid-tumor CAR T-cell therapy: linking programmable control to tissue pharmacodynamics. [PDF]

Front Immunol
Vo MC, Kim SK, Bae WK, Ruzimurodov N, Jung SH, Lee JJ.   +5 more
europepmc   +1 more source

Organ-specific depth of response to CD19-directed CAR T-cell therapy in B-cell lymphomas. [PDF]

Cancer Immunol Immunother
Kassube M, Achhammer P, Linden P, Bücklein VL, Tix T, Kruk L, Holzgreve A, Werner RA, Ricke J, von Bergwelt-Baildon M, Rejeski K, Subklewe M, Kunz WG, Winkelmann M.   +13 more
europepmc   +1 more source