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CAR T-cells for cancer therapy
Biotechnology and Genetic Engineering Reviews, 2017Chimeric antigen receptor (CAR) T-cells are redirected T-cells that can recognize cancer antigens in a major histocompatibility complex (MHC)-independent fashion. A typical CAR is comprised of two main functional domains: an extracellular antigen recognition domain, called a single-chain variable fragment (scFv), and an intracellular signaling domain ...
Niaz, Muhammad, Qinwen, Mao, Haibin, Xia
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Journal of Population Therapeutics and Clinical Pharmacology
There is rising interest in CAR-T therapy as a potential treatment of non-small cell lung cancer (NSCLC) that comprises about 85% of all lung cancer and has a high mortality rate. This is a new technology whereby T cells are engineered to attack certain tumor-specific antigens.
Dr. Renuka . +2 more
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There is rising interest in CAR-T therapy as a potential treatment of non-small cell lung cancer (NSCLC) that comprises about 85% of all lung cancer and has a high mortality rate. This is a new technology whereby T cells are engineered to attack certain tumor-specific antigens.
Dr. Renuka . +2 more
+4 more sources
Engineered T Cells: CAR T Cell Therapy and Beyond
Current Oncology Reports, 2022This article reviews the current data and future directions of engineered T cell therapies in non-Hodgkin lymphomas.Currently, four chimeric antigen receptor (CAR) T cell products are approved: axicabtagene ciloleucel, tisagenlecleucel, lisocabtagene maraleucel, and brexucabtagene autoleucel.
P Connor, Johnson, Jeremy S, Abramson
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CAR T-cell therapy for gliomas
Current Opinion in NeurologyPurpose of review To review the landscape of chimeric antigen receptor T-cell (CAR T) therapy for gliomas as seen in recently published trials and discuss on-going challenges with new cancer immunotherapy treatments. Recent findings Given how CAR T therapy has revolutionized the ...
Kun-Wei, Song, Brian J, Scott
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CAR T-cell therapy in autoimmune diseases
The Lancet, 2023Despite the tremendous progress in the clinical management of autoimmune diseases, many patients do not respond to the currently used treatments. Autoreactive B cells play a key role in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis.
Schett, Georg +2 more
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CAR T Cells and T-Cell Therapies for Cancer
JAMAImportance Chimeric antigen receptor (CAR) T cells are T lymphocytes that are genetically engineered to express a synthetic receptor that recognizes a tumor cell surface antigen and causes the T cell to kill the tumor cell.
Jennifer N, Brudno +2 more
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Critical Care Management of Chimeric Antigen Receptor T-Cell Therapy Recipients
Ca-A Cancer Journal for Clinicians, 2022Sandrine Valadè +2 more
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