Results 81 to 90 of about 810 (205)

Synthesis and Reactivity of 3‐Aminosydnones in Cycloaddition Reactions With Alkynes

Chemistry – A European Journal, EarlyView.
The synthesis, functionalization, and reactivity as dipoles of 3‐aminosydnones have been investigated. These neglected compounds undergo smooth cycloaddition reactions with strained alkynes, leading to 1‐aminopyrazoles. ABSTRACT We present in this article the synthesis, functionalization, and properties of 3‐aminosydnones, a forgotten class of ...
Apolline Dominic, Timothée D'anfray, Guillaume Force, David‐Alexandre Buisson, Maxime Tricoire, Alexis Leblais, Davide Audisio, Frédéric Taran   +7 more
wiley   +1 more source

Synthesis and Biological Evaluation of Well‐Defined M6P(n)‐Modified Glycopeptides for Targeted Protein Degradation

Chemistry – A European Journal, EarlyView.
A synthetic methodology has been developed to prepare multifunctional M6P and M6Pn ligands of different valency. The glycopeptides were conjugated to cetuximab and then examined to mediate cellular uptake of fluorescently labeled EGFRvIII. Only cetuximab modified by glycopeptides having 3 or 6 M6P or M6Pn residues demonstrated greater uptake.
Patrycja Lenartowicz, Jan‐Willem H. Langenbach, Nataliia Voloshyna, David Aidukas, Arwin J. Brouwer, John A. W. Kruijtzer, Geert‐Jan Boons   +6 more
wiley   +1 more source

Anti-Proliferative Activity of Ethylenediurea Derivatives with Alkyl and Oxygen-Containing Groups as Substituents

Biomedicines
Background/Objectives: Natural cytokinins are a promising group of anti-tumor agents. In this work, we hypothesized that modification of the ethylenediurea moiety with alkyl and oxygen-containing groups could be a way to enhance the anti-proliferative ...
Maxim Oshchepkov, Leonid Kovalenko, Antonida Kalistratova, Galina Sherstyanykh, Evgenia Gorbacheva, Alexey Antonov, Nisreen Khadour, Mikhail Akimov   +7 more
doaj   +1 more source

Late‐Stage Modification of Halotryptophan‐Containing Peptides Via Negishi Cross‐Coupling

Chemistry – A European Journal, EarlyView.
Negishi cross‐coupling provides access to the late‐stage functionalization of bromotryptophan‐containing peptides under comparatively mild conditions and is applicable to a range of peptide substrates in the investigated model systems. The examined alkyl iodides and variation of N‐terminal residues demonstrate the feasibility of the transformation in a
Laura Cerveson, Marcel‐Jannik Heldt, Norbert Sewald   +2 more
wiley   +1 more source

Mechanochemical Amidation Mediated by 1,1’‐Oxalyldiimidazole for the Synthesis of Agrochemicals

Chemistry – A European Journal, EarlyView.
Mechanochemical amidation using 1,1'‐oxalyldiimidazole (ODI) overcomes limitations of 1,1’‐carbonyl diimidazole (CDI) as coupling agent by enabling the efficient mechanochemical synthesis of three marketed agrochemicals from deactivated carboxylic acids.
Andrea Casagrande, Rubén Solorzano‐Rodriguez, Maria Carta, Francesco Delogu, Joris Vezzani, Allan Niidu, Evelina Colacino   +6 more
wiley   +1 more source

Studies on Carbamates. IX. The Carbamate of Allylamine. [PDF]

Acta Chemica Scandinavica, 1952
Arne Jensen, Ruth Christensen, Carl Faurholt   +2 more
openaire   +1 more source

Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release

Chemistry – A European Journal, EarlyView.
Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka, Marek Chovanec, Rastislav Dzijak, Michal Rahm, Jachym Hrusak, Paul E. Reyes‐Gutierrez, Milan Vrabel   +6 more
wiley   +1 more source

Studies on Carbamates. XII. The Carbamates of the Butylamines. [PDF]

Acta Chemica Scandinavica, 1957
Mogens Ballund Jensen, Göran Claeson, Gösta Pettersson   +2 more
openaire   +1 more source

Successive Azide and DNA Functionalization for Reversible and Controlled Association of Single‐Wall Carbon Nanotubes

Chemistry – A European Journal, EarlyView.
A newly synthesized bifunctional azide—diazonium linker allows robust one‐step introduction of azido groups to single‐wall carbon nanotubes. Versatility of the azido groups as reactive handles is demonstrated by further derivatization with 6‐carboxyfluorescein and oligonucleotides.
Razieh Moosavi, Tharun K. Kotammagari, Pia Damlin, Mikko Salomäki, Mika Lastusaari, Han Li, Tuomas Lönnberg   +6 more
wiley   +1 more source

Studies on Carbamates. VI. The Carbamate of Glycine. [PDF]

Acta Chemica Scandinavica, 1952
Arne Jensen, J. Buur Jensen, Carl Faurholt, Ernst Finsnes, Jörgine Stene Sörensen, Nils Andreas Sörensen   +5 more
openaire   +1 more source