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Therapeutic drug monitoring and methods of quantitation for carbamazepine [PDF]

Journal of Mind and Medical Sciences, 2017
Carbamazepine is an early anticonvulsant still used today in the treatment of several forms of epilepsy. An active metabolite in the human body contributes to its pharmacological effect.
Cristian Tuchila, Daniela L. Baconi, Cristina D. Pirvu, Denisa O. Balalau, Ana M. Vlasceanu, Miriana Stan, Cristian Balalau   +6 more
doaj   +5 more sources

Long‐term treatment with carbamazepine restores cognitive abilities in a mouse model of KCNQ2 developmental and epileptic encephalopathy [PDF]

Epilepsia Open
Objective Carbamazepine is the first line treatment for patients affected by KCNQ2 developmental and epileptic encephalopathy. It is efficient to reduce or stop seizures in this context.
Jordane Louis, Natalia Doudka, Marie‐Solenne Félix, Adeline Spiga Ghata, Camille Espanet, Romain Guilhaumou, Mathieu Milh, Laurent Villard   +7 more
doaj   +2 more sources

Accumulation and Subcellular Distribution Patterns of Carbamazepine in Hydroponic Vegetables [PDF]

Biology
Pharmaceutical and Personal Care Products (PPCPs), such as carbamazepine, enter the food chain through wastewater irrigation, posing risks to ecosystems and human health.
Sihan Yao, Yan Chen, Nan Zheng, Ting Chen, Sufen Zhang, Zhiyang Yu, Haiyan Wang   +6 more
doaj   +2 more sources

Carbamazepine Induces Platelet Apoptosis and Thrombocytopenia Through Protein Kinase A

Frontiers in Pharmacology, 2021
Carbamazepine is extensively used worldwide to treat a wide range of disorders such as epilepsy, peripheral neuralgia and bipolar disorder. Thrombocytopenia and hemorrhage have been identified in multiple carbamazepine-treated patients.
Weiling Xiao, Weiling Xiao, Kangxi Zhou, Mengnan Yang, Chenglin Sun, Lan Dai, Jian Gu, Rong Yan, Kesheng Dai   +8 more
doaj   +1 more source

Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug–Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach

Pharmaceutics, 2021
The anticonvulsant carbamazepine is frequently used in the long-term therapy of epilepsy and is a known substrate and inducer of cytochrome P450 (CYP) 3A4 and CYP2B6. Carbamazepine induces the metabolism of various drugs (including its own); on the other
Laura Maria Fuhr, Fatima Zahra Marok, Nina Hanke, Dominik Selzer, Thorsten Lehr   +4 more
doaj   +1 more source

The effect of multidrug exposure on neurological manifestations in carbamazepine intoxication: a nested case-control study

BMC Pharmacology and Toxicology, 2020
Background In acute intoxication, carbamazepine concentration above 40 mcg/ml is associated with a risk of severe neurological consequences, including depressed consciousness, respiratory depression, cardiac conduction disorders, seizures, and death ...
Ayala Hirsch, Maor Wanounou, Amichai Perlman, Bruria Hirsh-Raccah, Mordechai Muszkat   +4 more
doaj   +1 more source

Toxicokinetics and correlation of carbamazepine salivary and serum concentrations in acute poisonings [PDF]

Vojnosanitetski Pregled, 2012
Background/Aim. Saliva is a body fluid which, like serum, can be used for determination of concentrations of certain drugs, both in pharmacotherapy as well as in acute poisonings.
Đorđević Snežana, Kilibarda Vesna, Vučinić Slavica, Stojanović Tomislav, Antonijević Biljana   +4 more
doaj   +1 more source

Fabrication of Bi4O5Br2 photocatalyst for carbamazepine degradation under visible-light irradiation

Water Science and Technology, 2021
Bi4O5Br2 with irregular flake shape was synthesized by a facile and energy-saving hydrolysis method. Its band gap energy (Eg) was 2.1 eV. The formation mechanism was proposed.
Xiaoming Mao, Min Li, Mengyao Li
doaj   +1 more source

Plasma arginine vasopressin concentrations in epileptics under monotherapy [PDF]

, 1983
Plasma arginine vasopressin concentrations were determined by radio-immunoassay in 112 adult epileptics who were taking carbamazepine, phenytoin, primidone, or sodium valproate in long-term monotherapy, and in 19 controls.
E Perucca, E Perucca, K. -H. Krause, M Heim, MG Ashton, MP Fichman, NJ Smith, P Sordillo, P. Berlit, RL Marsland, T Kimura, TH Thomas, W Rascher, W. Rascher, WP Stephens, WP Stephens   +15 more
core   +1 more source

Carbamazepine overdose after exposure to simethicone: a case report

Journal of Medical Case Reports, 2008
Introduction Carbamazepine is an anticonvulsant drug and is also used as a treatment for patients with manic-depressive illness, post-herpetic neuralgia or phantom limb pain. The drug itself has many drug interactions. Simethicone is an antifoaming agent
Guneysel Ozlem, Onur Ozge, Denizbasi Arzu, Saritemur Murat   +3 more
doaj   +1 more source