Results 11 to 20 of about 56,505 (288)

Carbamazepine for schizophrenia [PDF]

Cochrane Database of Systematic Reviews, 2014
Many people with schizophrenia do not achieve a satisfactory treatment response with just antipsychotic drug treatment and various adjunct medications are used to promote additional response. The antiepileptic carbamazepine is one such drug.To examine whether carbamazepine or oxcarbazepine alone is an effective treatment for schizophrenia and ...
Stefan, Leucht, Bartosz, Helfer, Markus, Dold, Werner, Kissling, John, McGrath   +4 more
core   +4 more sources

Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion [PDF]

Case Reports in Medicine, 2015
Carbamazepine is a widely used anticonvulsant. Its metabolite, carbamazepine-10,11-epoxide, has been found to display similar anticonvulsant and neurotoxic properties. While the ratio of parent to metabolite concentration varies significantly, at therapeutic doses the epoxide concentration is generally about 20% of the parent. We report a case of fatal
Jason L. Russell, Henry A. Spiller, Daniel D. Baker   +2 more
openaire   +5 more sources

Activation of T cells by carbamazepine and carbamazepine metabolites

Journal of Allergy and Clinical Immunology, 2006
T-cell-mediated hypersensitivity is a rare but serious manifestation of drug therapy.To explore the mechanisms of drug presentation to T cells and the possibility that generation of metabolite-specific T cells may provoke cross-sensitization between drugs.A lymphocyte transformation test was performed on 13 hypersensitive patients with carbamazepine ...
Wu, Ying, Sanderson, Joseph P, Farrell, John, Drummond, Nicola S, Hanson, Anita, Bowkett, Elizabeth, Berry, Neil, Stachulski, Andrew V, Clarke, Stephen E, Pichler, Werner Joseph, Pirmohamed, Munir, Park, B Kevin, Naisbitt, Dean J   +12 more
openaire   +4 more sources

Carbamazepine

Reactions Weekly, 2015
Since the mid‐1960s, carbamazepine has been successfully used all over the world. The chemical structure of carbamazepine is similar to that of certain psychotropic drugs, such as imipramine, chlorpromazine and maprotiline.
Svein I. Johannessen, Tomson, T, Torbjörn Tomson, Johannessen, SI   +3 more
openaire   +2 more sources

Non-recurrence of carbamazepine induced vitiligo after rechallenge with carbamazepine.

Iranian Journal of Psychiatry, 2013
Objective: Vitiligo is a rare side effect of carbamazepine whose exact mechanism is unknown. The aim of this report is to describe a single case of vitiligo induced by carbamazepine .
Masoomeh Saeedloo, Seyed Vahid Shariat
doaj   +1 more source

Carbamazepine for schizophrenia [PDF]

, 2007
Many people with schizophrenia do not achieve a satisfactory treatment response with just antipsychotic drug treatment and various adjunct medications are used to promote additional response. The antiepileptic carbamazepine is one such drug.To evaluate the effects of carbamazepine and its derivatives for the treatment of schizophrenia and related ...
Leucht, Stefan, Kissling, Werner, McGrath, John, White, Paul   +3 more
openaire   +4 more sources

The epoxide of carbamazepine.

Clinical and experimental neurology, 1979
Simultaneous steady-state plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide have been measured by high pressure liquid chromatography in 101 epileptic children and adults taking the drug. There was either no statistically significant correlation, or only a very poor correlation, between drug dose and steady-state plasma levels of a)
McKauge, L., Tyrer, J. H., Eadie, M. J.
openaire   +3 more sources

Method of simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide by HPLC-MS/MS [PDF]

Регуляторные исследования и экспертиза лекарственных средств, 2018
Carbamazepine is the drug of first choice in the treatment of trigeminal neuralgia, epilepsy and other neurological diseases. Carbamazepine is known to have a narrow therapeutic range, and hereby the auto-induction of its metabolism with prolonged use ...
T. A. Rodina, E. S. Melnikov, A. V. Sokolov, A. B. Prokofiev, V. V. Arkhipov, G. V. Adamov, D. L. Pozdnyakov, Yu. V. Olefir   +7 more
doaj   +1 more source

Physiologically Based Pharmacokinetic Modeling to Assess Transporter-Mediated Drug-Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray. [PDF]

Clin Pharmacol Ther
Zavegepant nasal spray, a calcitonin gene‐related peptide receptor antagonist indicated for acute treatment of migraine with or without aura in adults, is a substrate for organic anion transporting polypeptide 1B3 (OATP1B3), Na+/taurocholate cotransporting polypeptide (NTCP), P‐glycoprotein (P‐gp), and cytochrome P450 3A4 (CYP3A4).
Ke A, Callegari E, Varma MVS, Ladumor MK, Muto C, Bertz RJ, Jones HM, Sahasrabudhe V, Liu J.   +8 more
europepmc   +2 more sources

Solution aggregation of two carbamazepine co-crystal systems as indication of nucleation pathways [PDF]

, 2022
An investigation into the solution phase aggregation of carbamazepine/saccharin and carbmazepine/nicotinamide shows weak and strong interaction, respectively, though both systems co-crytallise easily.
Katharina, Edkins, Yichun, Shen
core   +2 more sources