Results 11 to 20 of about 120,317 (381)

Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug–Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach

Pharmaceutics, 2021
The anticonvulsant carbamazepine is frequently used in the long-term therapy of epilepsy and is a known substrate and inducer of cytochrome P450 (CYP) 3A4 and CYP2B6. Carbamazepine induces the metabolism of various drugs (including its own); on the other
Laura Maria Fuhr, Fatima Zahra Marok, Nina Hanke, Dominik Selzer, Thorsten Lehr   +4 more
doaj   +2 more sources

Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients

Journal of Immunology Research, 2018
The HLA-B∗15:02 allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in Thai patients.
Chonlaphat Sukasem, Chonlawat Chaichan, Thapanat Nakkrut, Patompong Satapornpong, Kanoot Jaruthamsophon, Thawinee Jantararoungtong, Napatrupron Koomdee, Suthida Sririttha, Sadeep Medhasi, Sarawut Oo-Puthinan, Ticha Rerkpattanapipat, Jettanong Klaewsongkram, Pawinee Rerknimitr, Papapit Tuchinda, Leena Chularojanamontri, Napatra Tovanabutra, Apichaya Puangpetch, Wichai Aekplakorn   +17 more
doaj   +2 more sources

Carbamazepine Enhances Adipogenesis by Inhibiting Wnt/β-Catenin Expression

Cells, 2019
Carbamazepine is a drug that is widely used in the treatment of epilepsy and bipolar disorder. The prevalence of obesity in patients treated with carbamazepine has been frequently reported.
Dong Uk Im, Sang Chon Kim, Gia Cac Chau, Sung Hee Um   +3 more
doaj   +2 more sources

Carbamazepine for schizophrenia [PDF]

Cochrane Database of Systematic Reviews, 2014
Many people with schizophrenia do not achieve a satisfactory treatment response with just antipsychotic drug treatment and various adjunct medications are used to promote additional response. The antiepileptic carbamazepine is one such drug.To examine whether carbamazepine or oxcarbazepine alone is an effective treatment for schizophrenia and ...
Stefan, Leucht, Bartosz, Helfer, Markus, Dold, Werner, Kissling, John, McGrath   +4 more
openaire   +3 more sources

Therapeutic drug monitoring and methods of quantitation for carbamazepine [PDF]

Journal of Mind and Medical Sciences, 2017
Carbamazepine is an early anticonvulsant still used today in the treatment of several forms of epilepsy. An active metabolite in the human body contributes to its pharmacological effect.
Cristian Tuchila, Daniela L. Baconi, Cristina D. Pirvu, Denisa O. Balalau, Ana M. Vlasceanu, Miriana Stan, Cristian Balalau   +6 more
doaj   +5 more sources

Long‐term treatment with carbamazepine restores cognitive abilities in a mouse model of KCNQ2 developmental and epileptic encephalopathy [PDF]

Epilepsia Open
Objective Carbamazepine is the first line treatment for patients affected by KCNQ2 developmental and epileptic encephalopathy. It is efficient to reduce or stop seizures in this context.
Jordane Louis, Natalia Doudka, Marie‐Solenne Félix, Adeline Spiga Ghata, Camille Espanet, Romain Guilhaumou, Mathieu Milh, Laurent Villard   +7 more
doaj   +2 more sources

Carbamazepine Induces Platelet Apoptosis and Thrombocytopenia Through Protein Kinase A

Frontiers in Pharmacology, 2021
Carbamazepine is extensively used worldwide to treat a wide range of disorders such as epilepsy, peripheral neuralgia and bipolar disorder. Thrombocytopenia and hemorrhage have been identified in multiple carbamazepine-treated patients.
Weiling Xiao, Weiling Xiao, Kangxi Zhou, Mengnan Yang, Chenglin Sun, Lan Dai, Jian Gu, Rong Yan, Kesheng Dai   +8 more
doaj   +1 more source

Efficacy of Carbamazepine and Its Derivatives in the Treatment of Bipolar Disorder

Medicina, 2021
Background and Objectives: This review is dedicated to the use of carbamazepine and its derivatives oxcarbazepine and eslicarbazepine in bipolar disorder and their relative strengths in treating and preventing new depressive or manic episodes. This paper
A. Grunze, B. Amann, H. Grunze
semanticscholar   +1 more source

The effect of multidrug exposure on neurological manifestations in carbamazepine intoxication: a nested case-control study

BMC Pharmacology and Toxicology, 2020
Background In acute intoxication, carbamazepine concentration above 40 mcg/ml is associated with a risk of severe neurological consequences, including depressed consciousness, respiratory depression, cardiac conduction disorders, seizures, and death ...
Ayala Hirsch, Maor Wanounou, Amichai Perlman, Bruria Hirsh-Raccah, Mordechai Muszkat   +4 more
doaj   +1 more source

Toxicokinetics and correlation of carbamazepine salivary and serum concentrations in acute poisonings [PDF]

Vojnosanitetski Pregled, 2012
Background/Aim. Saliva is a body fluid which, like serum, can be used for determination of concentrations of certain drugs, both in pharmacotherapy as well as in acute poisonings.
Đorđević Snežana, Kilibarda Vesna, Vučinić Slavica, Stojanović Tomislav, Antonijević Biljana   +4 more
doaj   +1 more source