Results 11 to 20 of about 61,637 (294)

Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug–Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach

Pharmaceutics, 2021
The anticonvulsant carbamazepine is frequently used in the long-term therapy of epilepsy and is a known substrate and inducer of cytochrome P450 (CYP) 3A4 and CYP2B6. Carbamazepine induces the metabolism of various drugs (including its own); on the other
Laura Maria Fuhr, Fatima Zahra Marok, Nina Hanke, Dominik Selzer, Thorsten Lehr   +4 more
doaj   +2 more sources

Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients

Journal of Immunology Research, 2018
The HLA-B∗15:02 allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in Thai patients.
Chonlaphat Sukasem, Chonlawat Chaichan, Thapanat Nakkrut, Patompong Satapornpong, Kanoot Jaruthamsophon, Thawinee Jantararoungtong, Napatrupron Koomdee, Suthida Sririttha, Sadeep Medhasi, Sarawut Oo-Puthinan, Ticha Rerkpattanapipat, Jettanong Klaewsongkram, Pawinee Rerknimitr, Papapit Tuchinda, Leena Chularojanamontri, Napatra Tovanabutra, Apichaya Puangpetch, Wichai Aekplakorn   +17 more
doaj   +2 more sources

Carbamazepine Enhances Adipogenesis by Inhibiting Wnt/β-Catenin Expression

Cells, 2019
Carbamazepine is a drug that is widely used in the treatment of epilepsy and bipolar disorder. The prevalence of obesity in patients treated with carbamazepine has been frequently reported.
Dong Uk Im, Sang Chon Kim, Gia Cac Chau, Sung Hee Um   +3 more
doaj   +2 more sources

Accumulation and Subcellular Distribution Patterns of Carbamazepine in Hydroponic Vegetables [PDF]

Biology
Pharmaceutical and Personal Care Products (PPCPs), such as carbamazepine, enter the food chain through wastewater irrigation, posing risks to ecosystems and human health.
Sihan Yao, Yan Chen, Nan Zheng, Ting Chen, Sufen Zhang, Zhiyang Yu, Haiyan Wang   +6 more
doaj   +2 more sources

Cilostazol geno-protective effects mitigate carbamazepine-induced genotoxicity in human cultured blood lymphocytes [PDF]

Toxicology Reports
Background: Carbamazepine is one of the most widely used antiepileptic drugs. Carbamazepine has been shown to be toxic to cells. Cilostazol, an antiplatelet agent, has known antioxidant, antiproliferative, anti-inflammatory, and anti-tumor effects ...
Enaam M. Al Momany, Abeer M. Rababa’h, Karem H. Alzoubi, Omar F. Khabour   +3 more
doaj   +2 more sources

Carbamazepine Induces Platelet Apoptosis and Thrombocytopenia Through Protein Kinase A

Frontiers in Pharmacology, 2021
Carbamazepine is extensively used worldwide to treat a wide range of disorders such as epilepsy, peripheral neuralgia and bipolar disorder. Thrombocytopenia and hemorrhage have been identified in multiple carbamazepine-treated patients.
Weiling Xiao, Weiling Xiao, Kangxi Zhou, Mengnan Yang, Chenglin Sun, Lan Dai, Jian Gu, Rong Yan, Kesheng Dai   +8 more
doaj   +1 more source

Efficacy of Carbamazepine and Its Derivatives in the Treatment of Bipolar Disorder

Medicina, 2021
Background and Objectives: This review is dedicated to the use of carbamazepine and its derivatives oxcarbazepine and eslicarbazepine in bipolar disorder and their relative strengths in treating and preventing new depressive or manic episodes. This paper
A. Grunze, B. Amann, H. Grunze
semanticscholar   +1 more source

Combined Structural and Plasmonic Enhancement of Nanometer-Thin Film Photocatalysis for Solar-Driven Wastewater Treatment [PDF]

ACS Applied Nano Materials, 6, 15204-15212, 2023, 2022
Titanium dioxide (TiO$_2$) thin films are commonly used as photocatalytic materials. Here, we enhance the photocatalytic activity of devices based on TiO$_2$ by combining nanostructured glass substrates with metallic plasmonic nanostructures. We achieve a three-fold increase of the catalyst's surface area through nanoscale three-dimensional patterning ...
arxiv   +1 more source

Removal of persistent organic contaminants from wastewater using a hybrid electrochemical-granular activated carbon (GAC) system [PDF]

Journal of Hazardous Materials Journal of Hazardous Materials, Volume 415, 5 August 2021, 125557, 2021
A three-dimensional (3D) electrochemical flow-through reactor equipped with GAC packed bed, polarized by the electric field, was evaluated for the removal of persistent organic contaminants from real sewage effluent. The performance of the reactor was investigated for 27 consecutive runs at two anodic current densities, i.e., low current density (LCD ...
arxiv   +1 more source

Dried Blood Spot Analysis for Simultaneous Quantification of Antiepileptic Drugs Using Liquid Chromatography–Tandem Mass Spectrometry [PDF]

Rapid Communications in Mass Spectrometry, Volume 39, Issue 16, 30 August 2025.
ABSTRACT Rationale Dried blood spot (DBS) sampling for the therapeutic drug monitoring of antiepileptic drugs offers practical advantages, including minimal invasiveness and ease of collection. However, for precise therapeutic management, its accuracy and reliability in quantification need to be validated.
Mariam M. Abady, Ji‐Seon Jeong, Ha‐Jeong Kwon   +2 more
wiley   +2 more sources