Results 191 to 200 of about 47,769 (294)

The human photosensitive epilepsy model for clinical proof‐of‐principle trials of novel antiseizure medications. 1. Use of the EEG in drug development and characteristics of the model

Epilepsia, EarlyView.
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof‐of‐principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalography (EEG) response (PPR) as a surrogate for seizures, is currently the only human model that allows POP trials of investigational compounds after ...
Dorothée Kasteleijn‐Nolst Trenité, Wolfgang Löscher   +1 more
wiley   +1 more source

Strain analysis of cardiac chambers in individuals with temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Cardiovascular impairment in people with epilepsy (PWE) has been attracting medical interest. This study investigated the myocardial strain of the four cardiac chambers of individuals with temporal lobe epilepsy, without known heart disease, compared to an age‐, sex‐, and body mass index‐matched control group.
Ramsés Miotto, Márcia Tatsch Cavagnollo, Katia Lin, Guilherme L. Fialho   +3 more
wiley   +1 more source

Extracting epilepsy‐related information from unstructured clinic letters using large language models

Epilepsia, EarlyView.
Abstract Objective The emergence of large language models (LLMs) and the increasing prevalence of electronic health records (EHRs) present significant opportunities for advancing health care research and practice. However, research that compares and applies LLMs to extract key epilepsy‐related information from unstructured medical free text is under ...
Shichao Fang, Ben Holgate, Anthony Shek, Joel S. Winston, Matthew McWilliam, Pedro F. Viana, James T. Teo, Mark P. Richardson   +7 more
wiley   +1 more source

Association of maternal epilepsy with perinatal outcomes, and an exploration of prenatal antiseizure medication: A population‐based retrospective cohort study

Epilepsia, EarlyView.
Abstract Objective(s) Pregnancy in women with epilepsy is associated with adverse perinatal outcomes, but debate remains as to role of epilepsy or of prenatal antiseizure medication (ASM), or both. We aimed to investigate the association between maternal epilepsy and perinatal outcomes, and to explore the role of prenatal ASM exposure.
Paolo Pieirino Mazzone, Jacqueline Stephen, Christopher J. Weir, Sohinee Bhattacharya, Mairead Black, Richard F. M. Chin   +5 more
wiley   +1 more source

Carbamazepine‐Induced Release of Serotonin from Rat Hippocampus In Vitro [PDF]

, 1998
John W. Dailey, Maarten E. A. Reith, Kevin R. Steidley, Joseph C. Milbrandt, Phillip C. Jobe   +4 more
openalex   +1 more source

Serum lipids, lipoproteins and apolipoproteins A and B in epileptic patients treated with valproic acid, carbamazepine or phenobarbital

, 1991
Elena P. Calandre, C.M. Rodriguez‐Lopez, A. Blazquez, David A. Cano   +3 more
openalex   +1 more source

Pharmacokinetic Analysis on Autoinduction of Carbamazepine Metabolism [PDF]

, 1996
Young-Ran Yoon, Jae‐Gook Shin, In‐June Cha, Kyung‐Ah Kim, Joo-Chul Shim, Younghoon Kim, Jongbeom Shin   +6 more
openalex   +1 more source

Broadening the phenotype associated with pathogenic variants in the FGF12 gene: From developmental and epileptic encephalopathy to drug‐responsive epilepsy with favorable cognitive outcome

Epilepsia, EarlyView.
Abstract The fibroblast growth factor 12 (FGF12) gene encodes a protein interacting with voltage‐gated sodium channels. Two variants, p.(Arg52His) and p.(Gly50Ser), have repeatedly been associated with developmental and epileptic encephalopathy‐47 (DEE47; Mendelian Inheritance in Man #617166) with poor outcome.
Clément Pierret, Florence Riccardi, Julien Neveu, Marie Alesandrini, Cécilia Altuzarra, Sébastien Boulogne, Maryline Carneiro, Nicolas Chatron, Bertrand Isidor, Laure Lacan, Gaëtan Lesca, Sylvie Nguyen, Diana Rodriguez, Sabrine Souci, Stéphanie Valence, Laurent Villard, Mathieu Milh, Béatrice Desnous   +17 more
wiley   +1 more source

Effect of the frequently used antiepileptic drugs carbamazepine, gabapentin, and pregabalin on the pharmacokinetics of edoxaban and other oral factor xa inhibitors in healthy volunteers. [PDF]

Front Pharmacol
Lenard A, Hermann SA, Stoll F, Burhenne J, Foerster KI, Czock D, Mikus G, Meid AD, Haefeli WE, Blank A.   +9 more
europepmc   +1 more source

Intersection of epilepsy and cardiac health: Insights from electrocardiography and syndromic associations

Epilepsia, EarlyView.
Abstract Epilepsy is a chronic neurological condition marked by recurrent, uncontrolled seizures. Identifying comorbidities in epilepsy is critical for preventing mortality. Among these, the autonomic nervous system's role in epilepsy often manifests as cardiac disorders. Patients with epilepsy (PWE), particularly those with poorly controlled seizures,
Enes Akyuz, Feyza Sule Aslan, Tugba Eyigurbuz   +2 more
wiley   +1 more source