A Pharmacokinetic Evaluation of a Pectin-Based Oral Multiparticulate Matrix Carrier of Carbamazepine
Background. Carbamazepine is a drug used in the treatment of neurological disorders such as epilepsy. However, due to its erratic absorption, oral bioavailability is often poor.
Seth Kwabena Amponsah+4 more
doaj +1 more source
Long-term effect of antiepileptic drug switch on serum lipids and C-reactive protein. [PDF]
BACKGROUND: Prior studies have shown that switching patients from inducing antiepileptic drugs (AEDs) to lamotrigine, levetiracetam, or topiramate reduces serum lipids and C-reactive protein (CRP). These studies were all of short duration, and some drugs,
Chervoneva, Inna+6 more
core +2 more sources
Acute Carbamazepine Intoxication
Carbamazepine is an anticonvulsant drug with multiple mechanisms of action, which condition the presence of a characteristic clinical picture after the overingestion of the drug. We expose a case report about a patient who, in the context of an attempted suicide, presented acute intoxication by benzodiazepines and carbamazepine, presenting the ...
María Dolores Calabria Gallego+1 more
openaire +3 more sources
Optimization and validation of bioanalytical SPE – HPLC method for the simultaneous determination of carbamazepine and its main metabolite, carbamazepine-10, 11-epoxide, in plasma [PDF]
Carbamazepine is widely used as an antiepileptic drug in the treatment of partial and generalized tonic-clonic seizures. Carbamazepine 10,11-epoxide is the most important metabolite of carbamazepine, because it is a pharmacologically active compound with
Jasmina Tonic – Ribarska+6 more
doaj
Cutaneous adverse reaction during lithium treatment: a case report and updated systematic review with meta-analysis [PDF]
OBJECTIVES: To present a new case of adverse cutaneous reaction during lithium treatment and to update the systematic review and meta-analysis of the incidence of this adverse reaction.
Manchia, Mirko+5 more
core +2 more sources
We assessed the efficacy and safety of once‐daily eslicarbazepine acetate in comparison with twice‐daily (BID) controlled‐release carbamazepine (carbamazepine‐CR) monotherapy in newly diagnosed focal epilepsy patients.
E. Trinka+7 more
semanticscholar +1 more source
Carbamazepine and Hematological Malignancies [PDF]
Received/Gelis tarihi : May 1, 2013 Accepted/Kabul tarihi : June 10, 2013 To the Editor, The letter entitled “Carbamazepine and Multiple Myeloma: Possible Interaction”, written by Gunaldi et al. [1] and published in one of the recent issues of your journal, was quite interesting. We would like to emphasize some points about that letter. In the reported
Gokhan Sargin+2 more
openaire +3 more sources
Carbamazepine is the main option used as a preventive medication to treat bipolar disorder when there is no response to lithium. Carbamazepine toxicity is defined as serum levels greater than 12 μg/mL, with severe toxicity occurring over 40 μg/mL ...
Lucia Fernández-López+5 more
doaj +1 more source
Efficacy and safety of eslicarbazepine acetate monotherapy in patients converting from carbamazepine. [PDF]
OBJECTIVE: To evaluate the influence of prior use of carbamazepine (CBZ) and other antiepileptic drugs (AEDs) with a putatively similar mechanism of action (inhibition of voltage-gated sodium channels; VGSCs) on seizure outcomes and tolerability when ...
Abou-Khalil+11 more
core +2 more sources
Co-crystal structures of furosemide:urea and carbamazepine:indomethacin determined from powder x-ray diffraction data [PDF]
Co-crystallization is a promising approach to improving both the solubility and the dissolution rate of active pharmaceutical ingredients. Crystal structure determination from powder diffraction data plays an important role in determining co-crystal ...
Al Rahal, Okba+4 more
core +2 more sources