Results 141 to 150 of about 862,573 (173)

Molecular Insights Into Hypervirulent Klebsiella pneumoniae: Identification and Correlation of Virulence Determinant

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Genotypic characterization of 82 clinical K. pneumoniae isolates identified 34 hypervirulent strains. The peg‐344 most strongly associated with hypervirulence (p = 0.0001) but with only 58.8% sensitivity and no signal in over 40% of hvKP isolates, it's a confirmatory marker, not a standalone diagnostic. ABSTRACT Klebsiella pneumoniae is an increasingly
Fathy M. Elkady, Nosiba S. Basher, Mohammed S. Abdulrahman, Amr H. Hashem, Rafik Abdellatif Metwally, Ahmed Abdel Tawab, Ebrahim Saied, Nasir A. Ibrahim, Mohammed Aufy   +8 more
wiley   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Carbapenem-resistant Klebsiella pneumoniae: the role of plasmids in emergence, dissemination, and evolution of a major clinical challenge

Klebsiella pneumoniae is a major agent of healthcare-associated infections and a cause of some community-acquired infections, including severe bacteremic infections associated with metastatic abscesses in liver and other organs.
Simona Pollini (304648), Marco Maria D’Andrea (8477952), Vivi Miriagou (17872074), Vincenzo Di Pilato (5807162), Gian Maria Rossolini (141530)   +4 more
core   +1 more source

Alveolar Macrophages: Development, Respiratory Homeostasis, Signal Pathways, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
Alveolar macrophages: development, respiratory homeostasis, signal pathways, diseases, and therapeutic opportunities: During embryonic development, fetal progenitors migrate to the developing lungs via a CX3CR1‐dependent mechanism to establish the TrAM pool.
Sihan Yang, Ruomeng Li, Chuanjiang Yu, Jing Li, Xikun Zhou   +4 more
wiley   +1 more source

Comparative Neurotoxicity of Polymyxin B and Colistin in Patients With Cancer

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 10, October 2026.
ABSTRACT Background The polymyxins, polymyxin B and colistin, are last‐line options for the treatment of infections caused by drug‐resistant gram‐negative organisms. The comparative neurotoxicity of these agents using contemporary dosing is poorly understood.
Samuel L. Aitken, Emily R. Aboujaoude, Jovan Borjan, Frank P. Tverdek   +3 more
wiley   +1 more source

Conserved Asp233–Asp246 hydrogen bond modulates active site dynamics in class A β‐lactamases

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Rigid enzymes catalyze chemical reactions by stabilizing the transition state through a specific conformation. Catalytic residues are precisely positioned, and enzyme dynamics are kept to a minimum. It is thought that conserved residues around the active site (second‐shell residues) play a crucial role in positioning catalytic residues. Asp233
Cristina V. Lopez‐Gallego, Monika Timmer, Jocelyne Vreede, Marcellus Ubbink   +3 more
wiley   +1 more source

Polymersome‐Enabled Multimodal Delivery of Tobramycin and Doripenem for Targeted Eradication of Pseudomonas aeruginosa Biofilms in Chronic Rhinosinusitis

Small, Volume 22, Issue 60, 27 October 2026.
Schematic representation of diffusion‐based versus pH‐triggered drug release within a bacterial biofilm. In diffusion‐based systems, drug cargo is gradually released independent of local pH, resulting in rapid burst release and reduced sustained concentrations.
Amalie Kjær Andresen, Matteo Tollemeto, Alexander B. Cook, Claus Sternberg, Yudong Li, Claus Moser, Lars Jelsbak, Jan C. M. Van Hest, Anja Boisen, Line Hagner Nielsen   +9 more
wiley   +1 more source

Antimicrobial Resistance Under a Changing Climate

Journal of the Royal Society of New Zealand, Volume 56, Issue 5, October 2026.
The landscape of antimicrobial resistance (AMR) is changing across the animal, human and environmental ecosphere, with both climate change and AMR recognised as leading threats to human health. In this viewpoint, we argue that climate change is likely to reshape the conditions under which AMR emerges, persists and spreads, with important implications ...
Annette Bolton, Isabelle Pattis, Sarah Nelson, Louise Weaver, Angela Baschieri, Ethan Williams   +5 more
wiley   +1 more source

Antibiotic Stewardship in Cirrhosis: Current Recommendations and Clinical Challenges

United European Gastroenterology Journal, Volume 14, Issue 8, October 2026.
ABSTRACT Bacterial infections are a major cause of mortality in cirrhosis, with antibiotic prophylaxis and empirical treatment embedded in international guidelines. However, the prevalence of multidrug‐resistant organisms and the epidemiology of infections have shifted considerably in recent decades.
Solaiman Ezzafzafi, Kimberly K. I. M. Bot, Lucas H. P. Bernts, Reinier M. van Hest, Alastair O'Brien, Michiel A. van Agtmael, Jarne M. van Hattem, Marten A. Lantinga   +7 more
wiley   +1 more source

Empirical Meropenem Versus Piperacillin/Tazobactam for Critically Ill Adults With Sepsis: Feasibility of a Randomised Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 9, October 2026.
ABSTRACT Background Meropenem and piperacillin/tazobactam are commonly used empirical antibiotics in critically ill adults with sepsis, but whether one is superior to the other is uncertain. Methods The Empirical Meropenem versus Piperacillin/Tazobactam for Adult Patients with Sepsis (EMPRESS) trial is an ongoing investigator‐initiated, randomised ...
Nick Frørup Meier, Morten Hylander Møller, Maj‐Brit Nørregaard Kjær, Fredrik Sjövall, Marie Warrer Munch, Benjamin Skov Kaas‐Hansen, Hans‐Christian Thorsen‐Meyer, Bodil Steen Rasmussen, Marie Helleberg, Frederik Boëtius Hertz, Theis Lange, Aksel Karl Georg Jensen, Lars Wiuff Andersen, Jakob Steen Andersen, Jens Michelsen, Lars Peter Kloster Andersen, Morten Heiberg Bestle, Anne Craveiro Brøchner, Theis Skovsgaard Itenov, Steffen Christensen, Ronni Thermann Reitz Plovsing, Klaus Ulrik Koch, Anders Møller, Olav Lilleholt Schjørring, Naia Bech Cranø, Kasper Vamdrup‐Andersen, Davide Placido, Tine Sylvest Meyhoff, Carl Thomas Anthon, Aske Tøgern, Milda Grigonyte‐Daraskeviciene, Zemira Engbakken, Anne Witte Kamstrup, Kis Rønn Uhre, Jehad Ahmad Barakji, Rikke Faebo Larsen, Anders Perner, Anders Granholm   +37 more
wiley   +1 more source