Results 101 to 110 of about 35,000 (274)

Mechanism for carbapenem resistance of clinical Enterobacteriaceae isolates

Experimental and Therapeutic Medicine, 2017
Carbapenemase-producing 'super bacteria', particularly NDM-1 and its variants, have become a major public health concern worldwide. The present study aimed to explore the molecular mechanism for carbapenem resistance of clinical Enterobacteriaceae isolates.
Yafei Ye, Lijuan Xu, Zhe Chen, Liang Ming, Yanping Han, Cailin Liu   +5 more
openaire   +3 more sources

Carbapenem resistance profile amongst Escherichia coli and Klebsiella pneumoniae in a tertiary care hospital in Ahmednagar, Maharashtra [PDF]

, 2014
Introduction: Carbapenem-resistant Enterobacteriaceae (CRE), specially three species of the Enterobacteriaceae family, the Klebsiella, Enterobacter and Escherichia have developed resistance to a group of antibiotics called “Carbapenems”, which are ...
Shraddha Prasad Gunjal, Prasad Niranjan Gunjal, Nagaraju Vanaparthi, Kher Sudheer
core   +1 more source

Genomic Characterization of Pan‐Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Klebsiella pneumoniae isolate KPNW showed resistance to all clinically relevant antibiotics. Upon whole genome sequencing and characterization, we detected a large number of antimicrobial resistance genes, resistance‐associated point mutations, virulence determinants, heavy metal resistance genes, and mobile genetic elements in errorits genome ...
Md. Wahid Murad, G. M. Shah Poran, Kalpana Baidya, Nazmul Ahsan   +3 more
wiley   +1 more source

A systematic review and meta-analysis of carbapenem resistance and its possible treatment options with focus on clinical Enterobacteriaceae: Thirty years of development in Pakistan

Heliyon
Background: Carbapenem resistance is epidemic worldwide, these last resort antimicrobials are listed in the WHO ‘watch group’ with higher resistance potential.
Muhammad Umair, Timothy R. Walsh, Mashkoor Mohsin   +2 more
doaj   +1 more source

Environmental Antimicrobial Resistance: Key Drivers, Hotspots, Innovative Strategies, and Challenges in the Fight Against Superbugs

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Antimicrobial resistance (AMR) poses a critical threat to global health, affecting humans, animals, and the environment. This review explores major drivers and hotspots of AMR and outlines innovative strategies, including One Health–based interventions, to mitigate the spread of resistant pathogens and address this escalating worldwide health challenge.
Kindu Alem, Mulat Dagnew, Mucheye Gizachew, Baye Gelaw, Feleke Moges   +4 more
wiley   +1 more source

Treatment of infections caused by multidrug-resistant Gram-negative bacteria:Report of the British Society for Antimicrobial Chemotherapy/Healthcare Infection Society/British Infection Association Joint Working Party [PDF]

, 2018
The Working Party makes more than 100 tabulated recommendations in antimicrobial prescribing for the treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria (GNB) and suggest further research, and algorithms for hospital and ...
Enoch, David A, Hawkey, Peter M, Livermore, David M, McNulty, Cliodna A M, Otter, Jonathan A, Warren, Roderic E, Wilson, A Peter R   +6 more
core   +1 more source

Comparison of Molecular and Phenotypic Methods for the Detection and Characterization of Carbapenem Resistant Enterobacteriaceae [PDF]

, 2016
In recent years, there has been a rapid dissemination of carbapenem resistant Enterobacteriaceae (CRE). This study aimed to compare phenotypic and molecular methods for detection and characterization of CRE isolates at a large tertiary care hospital in ...
Absar, Muhammad M., Abukhalid, Norah, Garaween, Ghada A., Senok, Abiola C., Somily, Ali M.   +4 more
core   +1 more source

Advances in Small Molecule Inhibitors Targeting the Bacterial Lipoprotein Transport System (Lol) in Gram‐Negative Bacteria

Chemistry – An Asian Journal, Volume 20, Issue 17, September 4, 2025.
The lipoprotein transport system (Lol) is a crucial target for combating multidrug‐resistant gram‐negative bacteria. This review discusses the structural and functional aspects of the LolABCDE complex, recent advances in small‐molecule inhibitors, and challenges, such as permeability and resistance.
Saemee Song, Su Yong Shim
wiley   +1 more source

Gram-Negative Bacteria Bloodstream Infections in Patients with Hematological Malignancies – The Impact of Pathogen Type and Patterns of Antibiotic Resistance: A Retrospective Cohort Study

Infection and Drug Resistance, 2021
Yishu Tang,1 Cong Xu,2 Han Xiao,2 Liwen Wang,2 Qian Cheng,2 Xin Li2 1Department of Emergency, The Third Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 2Department of Hematology, The Third Xiangya Hospital ...
Tang Y, Xu C, Xiao H, Wang L, Cheng Q, Li X   +5 more
doaj  

An Evaluation of Alternative Treatment Strategies in Mitigating Colistin Resistance: Targeting Plasmid Transfer Through the Use of Bambermycin or the Protein Coded by the Mcr‐1 Gene With Antibodies and Streptomycin

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
Bambermycin showed synergistic effect with colistin on mcr‐1 positive E. coli strains. Colistin and MCR‐1 antibody mixture showed additive lethal effect on mcr‐1 strains. Bambermycin had no effect on the transfer of mcr‐1 bound plasmids between organisms.
Ibrahim Z. Hassan, Daniel N. Qekwana, Vinny Naidoo   +2 more
wiley   +1 more source