Results 21 to 30 of about 145,606 (355)

Clinical impact of carbapenems in critically ill patients with valproic acid therapy: A propensity-matched analysis

open access: yesFrontiers in Neurology, 2023
BackgroundValproic acid (VPA) is one of the most widely used broad-spectrum antiepileptic drugs, and carbapenems (CBPs) remain the drug of choice for severe infection caused by multidrug-resistant bacteria in critically ill patients.
Shu-Chen Hsiao   +4 more
doaj   +1 more source

Phenotypic detection of Metallo-β-Lactamase in imipenem-resistant Pseudomonas aeruginosa and Stenotrophomonas maltophilia at Schiphra Hospital of Ouagadougou in Burkina Faso [PDF]

open access: yesMicrobes and Infectious Diseases, 2022
Background: Epidemic of carbapenemase-producing bacteria has become worldwide. Thus, during the last decade, the prevalence of carbapenem-resistant Enterobacteriaceae and non fermentative Gram-negative bacteria in human patients have increased ...
Boukaré Kaboré   +6 more
doaj   +1 more source

OXA-48 Carbapenemase-Producing Enterobacterales in Spanish Hospitals: An Updated Comprehensive Review on a Rising Antimicrobial Resistance

open access: yesAntibiotics, 2021
Carbapenemase-producing Enterobacterales (CPE) are significant contributors to the global public health threat of antimicrobial resistance. OXA-48-like enzymes and their variants are unique carbapenemases with low or null hydrolytic activity toward ...
Mario Rivera-Izquierdo   +9 more
doaj   +1 more source

Differential DNA accessibility to polymerase enables 30-minute phenotypic β-lactam antibiotic susceptibility testing of carbapenem-resistant Enterobacteriaceae [PDF]

open access: yes, 2020
The rise in carbapenem-resistant Enterobacteriaceae (CRE) infections has created a global health emergency, underlining the critical need to develop faster diagnostics to treat swiftly and correctly.
Garner, Omai B.   +5 more
core   +1 more source

Prevalence of hypervirulent and carbapenem-resistant Klebsiella pneumoniae under divergent evolutionary patterns

open access: yesEmerging Microbes and Infections, 2022
K1/K2 hvKP strains acquire carbapenem-resistance plasmids, known as CR-hvKp, and carbapenem-resistant Klebsiella pneumoniae (CRKP) strains obtain virulence plasmids, recognized as hv-CRKP.
Dongxing Tian   +8 more
semanticscholar   +1 more source

Prevalence of blaKPC-2, blaKPC-3 and blaKPC-30—Carrying Plasmids in Klebsiella pneumoniae Isolated in a Brazilian Hospital

open access: yesPathogens, 2021
Klebsiella pneumoniae carbapenemase (KPC) actively hydrolyzes carbapenems, antibiotics often used a last-line treatment for multidrug-resistant bacteria. KPC clinical relevance resides in its widespread dissemination.
Letícia B. Migliorini   +10 more
doaj   +1 more source

Polymorphic Crystallization Design to Prevent the Degradation of the β-Lactam Structure of a Carbapenem

open access: yesCrystals, 2021
The cooling crystallization of carbapenem CS-023 was performed at 25 °C in an aqueous solution. Tetrahydrate crystals (form H) were obtained. Hydrate crystals are promising drugs, but there has been problems in manufacturing such crystals. During cooling
Shinji Matsuura   +3 more
doaj   +1 more source

Carbapenem resistance in Acinetobacter baumannii, and their importance in hospital‐acquired infections: a scientific review

open access: yesJournal of Applied Microbiology, 2021
Carbapenem is an important therapy for serious hospital‐acquired infections and for the care of patients affected by multidrug‐resistant organisms, specifically Acinetobacter baumannii; however, with the global increase of carbapenem‐resistant A ...
M. Nguyen, S. Joshi
semanticscholar   +1 more source

Epidemiological characteristics and molecular evolution mechanisms of carbapenem-resistant hypervirulent Klebsiella pneumoniae

open access: yesFrontiers in Microbiology, 2022
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP), a type of Klebsiella pneumoniae (KP) that exhibits hypervirulence and carbapenem resistance phenotypes, can cause severe infections, both hospital- and community-acquired infections.
Yuqiao Han   +7 more
semanticscholar   +1 more source

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