Results 31 to 40 of about 28,387 (241)

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Comparison of Carbapenem vs. Amikacin Antimicrobial Therapy for Pediatric Acute Pyelonephritis Caused by Extended-Spectrum Β-Lactamase-Positive Enterobacteriaceae

Children
Objectives: Acute pyelonephritis (APN) caused by extended-spectrum β-lactamase (ESBL)-positive Enterobacteriaceae poses a growing therapeutic challenge in children, as carbapenems remain the mainstay of treatment even when susceptibility to alternative ...
Burcu Ceylan Cura Yayla, Tuğba Bedir Demirdağ, Anıl Tapısız, Yeşim Özdemir Atikel, Hasan Tezer, Elif Ayça Şahin, Kayhan Çağlar, Sevcan A. Bakkaloğlu, Necla Buyan   +8 more
doaj   +1 more source

Genomic analysis of carbapenem-resistant Klebsiella pneumoniae blood isolates from nationwide surveillance in South Korea

Frontiers in Microbiology
IntroductionCarbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant threat to public health owing to its multidrug resistance and rapid dissemination.MethodsThis study analyzed CRKP isolates collected from bloodstream infections in nine ...
Younggwon On, Jung Wook Kim, Juyoung Lee, Jung Sik Yoo   +3 more
doaj   +1 more source

Detection and Real-time PCR Assay for the Quantification of Carbapenemase Gene blablaNDM-1 in Hospital Effluent

Journal of Pure and Applied Microbiology, 2021
This study aims to isolate gram-negative bacteria (GNB) harboring the gene NDM-1 from the tertiary care hospital effluents. Also, aims to evaluate the relative copy number of blaNDM-1 carried by the positive isolates.
M. Divyashree, Madhu K. Mani, Shama Prakash K   +2 more
doaj   +1 more source

Carbapenem Resistance: A Review [PDF]

Medical Sciences, 2017
Carbapenem resistance is a major and an on-going public health problem globally. It occurs mainly among Gram-negative pathogens such as Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, and may be intrinsic or mediated by transferable carbapenemase-encoding genes.
Francis S. Codjoe, Eric S. Donkor
openaire   +3 more sources

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +2 more sources

Multiplex PCR for identification and β-lactam resistance gene detection in clinical isolates of Acinetobacter baumannii

Journal of Infection in Developing Countries
Introduction: Acinetobacter baumannii (A. baumannii) is a major cause of hospital-acquired infections and frequently harbors antibiotic-resistance genes that complicate treatment.
Anh T Nguyen, Trinh C Phan, Thuy BT Ngo, Thanh TT Nguyen, Linh TL Ho, Minh T Quang, Thai M Nguyen   +6 more
doaj   +1 more source

Utility of phenotypic methods in detection of metallo-beta-lactamases in gram-negative bacteria

Journal of Marine Medical Society, 2020
Background: Metallo-beta-lactamases (MBLs)-producing Gram-negative bacilli (GNB) are one of the significant multidrug-resistant pathogens causing healthcare-associated infection (HAI) worldwide.
Dinesh Kumar Kalra, Sanjay Pratap Singh, Ajay Kumar Sahni, Naveen Grover, Mahadevan Kumar, Deepti Kalra   +5 more
doaj   +1 more source

Genomic Features Associated with the Degree of Phenotypic Resistance to Carbapenems in Carbapenem-Resistant Klebsiella pneumoniae

mSystems, 2021
Carbapenem-resistant Klebsiella pneumoniae strains cause severe infections that are difficult to treat. The production of carbapenemases such as the K.
Zackery P. Bulman, Fiorella Krapp, Nathan B. Pincus, Eric Wenzler, Katherine R. Murphy, Chao Qi, Egon A. Ozer, Alan R. Hauser   +7 more
doaj   +1 more source

Clinical Characteristics and Outcome of MDR/XDR Bacterial Infections in a Neuromuscular Semi-Intensive/Sub-Intensive Care Unit

Antibiotics, 2022
(1) Background: The aim of this study was to assess the clinical and microbiological characteristics of multidrug-resistant infections in a neuromuscular semi-intensive/sub-intensive care unit; (2) Methods: Retrospective analysis on data from 18 patients
Arta Karruli, Alessia Massa, Lorenzo Bertolino, Roberto Andini, Pasquale Sansone, Salvatore Dongiovanni, Maria Caterina Pace, Vincenzo Pota, Emanuele Durante-Mangoni   +8 more
doaj   +1 more source