Results 41 to 50 of about 114,909 (286)

Results on the mandatory notification of carbapenem-resistant Gram-negative bacteria, Hesse, Germany, January 2012 – April 2013

GMS Infectious Diseases, 2014
Carbapenems are important therapeutic agents for treating infections caused by multidrug-resistant Gram-negative bacteria. Mandatory reporting of carbapenem-resistant Gram-negative bacteria (CR-GN) can allow for a better understanding of the changing CR ...
Hauri, Anja M., Kaase, Martin, Hunfeld, Klaus-Peter, Heinmüller, Petra, Imirzalioglu, Can, Wichelhaus, Thomas A., Fitzenberger, Jens, Wirtz, Angela   +7 more
doaj   +1 more source

Sparing carbapenem usage [PDF]

Journal of Antimicrobial Chemotherapy, 2017
Carbapenem resistance in Gram-negative bacteria is increasing in many countries and use of carbapenems and antibiotics to which resistance is linked should be reduced to slow its emergence. There are no directly equivalent antibiotics and the alternatives are less well supported by clinical trials.
openaire   +3 more sources

Complete genome of the multidrug-resistant Acinetobacter baumannii strain KBN10P02143 isolated from Korea

Memorias do Instituto Oswaldo Cruz, 2016
Acinetobacter baumannii, a strictly aerobic, non-fermentative, Gram-negative coccobacillary rod-shaped bacterium, is an opportunistic pathogen in humans. We recently isolated a multidrug-resistant A. baumannii strain KBN10P02143 from the pus sample drawn
Yong-Woon Lee, Hanna Choe, Sang-Heon Lee, Kyung Mo Kim, Sin Kam, Byung Kwon Kim, Won-Kil Lee   +6 more
doaj   +1 more source

Investigation of Antibiotic Susceptibilities in Carbapenem-Resistant Klebsiella pneumoniae and Escherichia coli Strains Isolated from Clinical Samples: A Four-Year Analysis in a Comprehensive Healthcare Facility

Van Tıp Dergisi, 2023
INTRODUCTION: The profile of carbapenem-resistant Enterobacterales (CRE), antibiotic susceptibilities were analyzed in our hospital providing a wide range of healthcare services in Southeastern Anatolia.
Çiğdem Mermutluoğlu, Elif Zelal Çiftçi, Nida Özcan, Saim Dayan   +3 more
doaj   +1 more source

Interspecies DNA acquisition by a naturally competent Acinetobacter baumannii strain [PDF]

, 2019
The human pathogen Acinetobacter baumannii possesses high genetic plasticity and frequently acquires antimicrobial resistance genes. Here we investigated the role of natural transformation in these processes. Genomic DNA from different sources, including
Bahiense, Camila dos Santos, Bonomo, Robert A., Dotto, Cristian Marcelo, Fernandez, Jennifer, Iriarte, Andres, Melano, Roberto Gustavo, Montaña, Sabrina Daiana, Perez, Federico, Place, Kori, Ramirez, Maria Soledad, Soler Bistue, Alfonso J. C., Tolmasky, Marcelo E., Traglia, German Matias   +12 more
core   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Selection of Multidrug-Resistant Bacteria in Medicated Animal Feeds

Frontiers in Microbiology, 2019
Exposure to antimicrobial resistant (AMR) bacteria is a major public health issue which may, in part, have roots in food production practices that are conducive to the selection of AMR bacteria ultimately impacting the human microbiome through food ...
Emily E. F. Brown, Ashley Cooper, Catherine Carrillo, Burton Blais   +3 more
doaj   +1 more source

Antimicrobial Stewardship Program for Patients in the Hematological Department Receiving Carbapenem Therapy: A Single-Center and Interrupted Time Series Analysis

Antibiotics, 2023
As antibiotic resistance has become a global problem, the intervention of an antimicrobial stewardship team (AST) is warranted. In hematological disorders, infectious complications are crucial owing to abnormal neutrophil function and decreased cell ...
Ayako Suzuki, Fumihiro Yamaguchi, Masayuki Maeda, Miyuki Hashiguchi, Nobuyuki Kabasawa, Jun Sasaki, Tokutada Sato, Masaki Fuyama, Yohei Yamazaki, Kei Endo, Kae Iwata, Sei Kobayashi, Hisato Fujihara   +12 more
doaj   +1 more source

In-vitro evaluation of different antimicrobial combinations with and without colistin against carbapenem-resistant acinetobacter baumannii [PDF]

, 2019
Carbapenem-resistant Acinetobacter baumannii (CR-Ab) infections are associated with high morbidity and mortality. The aim of the study was to evaluate the in-vitro activity of different antimicrobial combinations (with and without colistin, COL) against ...
De Angelis, Massimiliano, Garzoli, Stefania, Marzuillo, Carolina, Mastroianni, Claudio M., Oliva, Alessandra, Ragno, Rino, Vullo, Vincenzo   +6 more
core   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source