Results 71 to 80 of about 11,730,789 (176)

Structural compatibility between β‐lactams and substrate binding pockets of IMP‐1 and NDM‐1 determines the substrate spectrum

Bulletin of the Korean Chemical Society, EarlyView.
Chemical structures of three β‐lactam classes and the substrate‐binding pockets (SBPs) of B1 metallo‐β‐lactamases (MBLs) were compared. Structural compatibility between β‐lactams and MBL SBPs correlates with enzymatic activity, providing insights into the substrate spectrum of MBLs and β‐lactam resistance.
Kiwoong Kwak, Jiwon Yun, Donghyun Lee, Byung‐Jin Lee, Juyeon Lim, Jung Hun Lee, Sang Hee Lee, Soon Young Shin, Lin‐Woo Kang   +8 more
wiley   +1 more source

Comparison of Modified Carbapenem Inactivation Method (mCIM) with Novel Rapid Carbapenemase Detection Method (rCDM) for Detection of Carbapenemase-Producing Organisms from Clinical Isolates

Pakistan Armed Forces Medical Journal
Objective: To determine the diagnostic accuracy of rapid Carbapenemase detection method (rCDM) for the detection of Carbapenemase-producing organisms, keeping the modified carbapenem inactivation method (mCIM) as the reference method Study Design ...
Asad Zafar, Irfan Ali Mirza, Sakeenah Hussain Naqvi, Anam Imtiaz, Adeel Gardezi, Rabia Sajjad   +5 more
doaj   +1 more source

Does the presence of multiple β-lactamases in Gram-negative bacilli impact the results of antimicrobial susceptibility tests and extended-spectrum β-lactamase and carbapenemase confirmation methods?

Journal of Global Antimicrobial Resistance, 2020
Objectives: Many multidrug-resistant Gram-negative bacilli (MDR-GNB) harbour multiple β-lactamases. The aim of this study was to assess the impact of multiple β-lactamase carriage on the accuracy of susceptibility tests and extended-spectrum β-lactamase (
Fred C. Tenover, Caitlin M. dela Cruz, Scott Dewell, Victoria M. Le, Isabella A. Tickler   +4 more
doaj   +1 more source

Lactobacillus derived small RNAs protect against Klebsiella pneumoniae infection

iMeta, EarlyView.
This study reveals that plant‐derived natural products confer protection against carbapenem‐resistant Klebsiella pneumoniae (CRKP) infection via remodeling the gut microbiota, with Lactobacillus identified as the core beneficial genus. Mechanistically, Lactobacillus murinus (L.
Tingting Xu, Xiuying Tao, Dan Fang, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +5 more
wiley   +1 more source

In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment

, 2009
We recovered a carbapenem-resistant Klebsiella pneumoniae isolate H224 under in vivo meropenem selection pressure. Insertional inactivation of a major porin gene, ompK36, by IS5 element might play a role in acquiring carbapenem resistance in this strain ...
이경원, 정석훈, 최준용, Seong Geun Hong, Kyungwon Lee, Young Ki Lee, Borum Suh, Jun Yong Choi, Eun Hee Jeon, Wonkeun Song, Seok Hoon Jeong   +10 more
core   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Evolutionary and Epidemiological Characterization of Multidrug‐Resistant Escherichia coli Isolated From Pangolins in China

Integrative Zoology, EarlyView.
ABSTRACT Malayan pangolin populations have fallen to a critically endangered level, and illegal trafficking of wild pangolins is a global problem. Little is known about antimicrobial‐resistant bacteria (MDRB) harbored by pangolins, although pangolins are frequently consumed as food or used in traditional medicine. In this study, we report for the first
Yawen Wang, Xue Wang, Jianan Zhao, Jun Zeng, Shijia Hu, Fang Ji, Guoying Dong, Hongxuan He, Chengmin Wang   +8 more
wiley   +1 more source

Characteristics of Carbapenem-Resistant Gram-Negative Bacilli in Patients with Ventilator-Associated Pneumonia

, 2021
Carbapenem-resistant Gram-negative bacilli (CR-GNB) has become a global threat. In hospital settings, the association of CR-GNB with ventilator-associated pneumonia (VAP) is a critical public health concern owing to their high resistance rate to most ...
Amira Mohamed, Enas Daef, Amany Nafie, Maggie Ibrahim, Lamia Shaban   +4 more
core   +1 more source

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

Andrology, EarlyView.
ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli, Salomé Gallissian, Roxanne Barèges, Félicia Fournier, Catherine Metzler‐Guillemain, Ségolène Prades, Fanny Magnan‐Sebag, Jeanne Perrin   +7 more
wiley   +1 more source

Detection of carbapenemase production in Enterobacterales by mCIM and eCIM: a tertiary care hospital study

Iranian Journal of Microbiology
Background and Objectives: Carbapenem-resistant Enterobacterales (CRE) pose a major healthcare challenge due to high resistance rates and limited treatment options.
Touseefa Shafi, Anjum Ara Mir, Shagufta Roohi, Bashir Fomda, Sanam Rasool Wani, Tufail Ahmed, Samiah Yousuf   +6 more
doaj   +1 more source