Results 161 to 170 of about 56,937 (260)

Computational design of a soluble mimic of the outer membrane LPS transport protein LptD suitable for screening of antibiotics

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Lipopolysaccharides (LPS) are the principal chemical component of the outer leaflet of Gram‐negative bacteria and constitute the first barrier of defense against foreign molecules. Inhibition of LPS transport presents a novel concept for antibiotic discovery, and components of the transport bridge are targets of antimicrobial peptides. LptD, a
Wenzhao Dai, Wenxuan Hu, Matthias Schuster, Laetitia Rožić, Bernd Roschitzki, Oliver Zerbe   +5 more
wiley   +1 more source

AEG‐AESPANC‐OPGE‐SIED‐SPG Ibero‐Latin American Guidelines on Acute Pancreatitis (iLATAM‐AP)

United European Gastroenterology Journal, Volume 14, Issue 5, June 2026.
ABSTRACT Introduction Acute pancreatitis (AP) is a major cause of gastrointestinal hospitalizations worldwide. Although typically self‐limiting, up to one‐third of cases develop complications associated with increased morbidity and mortality. Despite recent advances that have improved outcomes, clinical heterogeneity necessitates updated, evidence ...
Karina Cárdenas‐Jaén, Lucía Guilabert, Emma Martínez‐Moneo, Carla Mancilla, Miguel Bispo, Pedro Moutinho‐Ribeiro, Rodrigo Mansilla, Andreia Rei, Ana García García de Paredes, Antonio López‐Serrano, Bruno Rosa, Claudia Sánchez‐Marín, Daniel de la Iglesia, Edson Guzmán‐Calderon, Eduardo Rodrigues‐Pinto, Eva Marín‐Serrano, Fabio Ausania, Fauze Maluf‐Filho, Guido Villagómez, Humberto Cristino, Isabel Pascual‐Moreno, José A. Gonzalez, José M. Ramia, João Lopes‐Delgado, Lucas Granero, Mario Peláez‐Luna, María Francisco, Natalia Corzo‐Zamora, Ricardo Rio‐Tinto, Rómulo D. Vargas, Sandra Basso, Susana Lopes, Susana Marques, William Manzanares, Zoltán Berger, Irene Carrillo, José Joaquín Mira‐Solves, Alberto Espino, Adriana Cowdin, Alejandro Piscoya, Alexandra Fernandes, Noelia Rodríguez‐Ferreiro, Neftalí Jara Pérez‐López, Beatriz Valero, Enrique de‐Madaria   +44 more
wiley   +1 more source

Multiplex visual nucleic acid detection via isothermal cascaded transcription of fluorescent RNA aptamers

VIEW, Volume 7, Issue 3, June 2026.
(1) Existing multiplex nucleic acid detection struggles to combine high sensitivity, visual readout, and instrument‐free use, which is vital for rapid infection and antibiotic resistance diagnosis. (2) We developed MAGIC, integrating isothermal cascaded amplification and fluorescent RNA aptamer transcription, achieving 10 aM sensitivity, 100% accuracy ...
Yu Tang, Na Luo, Binbin Xie, Jie Luo, Yaling Yuan, Junjie Fan, Zhiyong Liu, Haiyan Gao, Ming Chen, Kai Chang   +9 more
wiley   +1 more source

Cefdinir binding to a class A β‐lactamase revealed by serial cryo‐crystallography

Acta Crystallographica Section D, Volume 82, Issue 6, Page 672-682, June 2026.
Serial cryo‐crystallography reveals the structure of the extended‐spectrum β‐lactamase CTX‐M‐14 in complex with the third‐generation cephalosporin antibiotic cefdinir.One of the most common resistance mechanisms against antibiotics employed by Gram‐negative bacteria involves the production of β‐lactamases, resulting in rapid hydrolysis of the ...
Gargi Gore, Andreas Prester, Kim Bartels, David von Stetten, Eike C. Schulz   +4 more
wiley   +1 more source

Isolation of a Novel Lytic Pseudomonas aeruginosa Phage Henu5 and Fitness Costs of Phage‐Driven Resistance

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
This study isolated and identified a novel lytic phage that infects Pseudomonas aeruginosa. Henu5 exhibited good physicochemical stability. Additionally, the phage‐resistant mutants showed fitness trade‐offs in growth, virulence and antibiotic susceptibility, along with in vivo fitness, which might direct future phage selection in clinical settings ...
Salwa E. Gomaa, Jiawen Shen, Jingjing Li, Yangyang Liu, Chaonan Ma, Qiming Li, Guanbin Qi, Tieshan Teng   +7 more
wiley   +1 more source

Antimicrobial Secondary Metabolites From Rhizosphere‐Associated Streptomyces Species in Northern Nigerian Agricultural Soils: Genomic Mining and Bioactivity Assessment

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
Nigerian agricultural soils harbour diverse Streptomyces species producing novel antimicrobial secondary metabolites. Genomic mining revealed 187 biosynthetic gene clusters, leading to isolation of twelve new compounds with potent activity against multidrug‐resistant pathogens, including MRSA and vancomycin‐resistant Enterococcus. ABSTRACT Streptomyces
David Adeiza Zakari, Sarafadeen Olateju Kareem, Obuotor Tolulope Mobolaji, Akinloye Oluseyi Adeboye, Adefila Moyosore Adebimpe   +4 more
wiley   +1 more source

Carbapenem-Resistant Enterobacterales in the Western Balkans: Addressing Gaps in European AMR Surveillance Map

In the context of global efforts to combat antimicrobial resistance (AMR), the importance of comprehensive AMR data is more crucial than ever. AMR surveillance networks, such as the European Antimicrobial Resistance Surveillance Network (EARS-Net) and ...
Snezana Brkic, Ivana Cirkovic
core   +1 more source

Novel Insights into Carbapenem Resistance: Mechanisms, Diagnostics, and Future Directions. [PDF]

Antibiotics (Basel)
Miftode IL, Radu VD, Jigoranu RA, Leca DA, Prepeliuc CS, Pasare MA, Miftode RS, Grigoriu MG, Parângă TG, Miftode EG.   +9 more
europepmc   +1 more source

Modulation of Quorum Sensing and Virulence Gene Expression in Escherichia coli by Extracts of Physalis alkekengi

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
Root extracts of Physalis alkekengi were examined for activity against multidrug‐resistant (MDR) Escherichia coli. The ethanolic extract suppressed bacterial growth, lowered biofilm formation by ~63%, and markedly reduced expression of luxS and fimH. Findings highlight P.
Mansoureh Esfandiyari Doolaby, Mohammad Javad Mehdipour Moghaddam, Akbar Norastehnia   +2 more
wiley   +1 more source

Carbapenem resistance in community-acquired urinary tract infections caused by <i>Klebsiella pneumoniae</i> and <i>Escherichia coli</i> in Morocco: a multicentre study (January 2022-December 2023): '<b>Carbapenem resistance in community UTIs in Morocco'</b>. [PDF]

JAC Antimicrob Resist
Khazaz A, El Otmani F, Benzaarate I, Bourjilat F, El Hamouchi A, Rafetrarivony LF, Huynh BT, Crucitti T, Brisse S, Nayme K.   +9 more
europepmc   +1 more source