Results 31 to 40 of about 29,439 (214)

Carbapenemases

, 2019
Carbapenems are usually regarded as the last treatment option for serious infections caused by Gram-negative and Gram-positive microorganisms. Although they are stable to hydrolysis by most β- lactamases, their usage as the last resort antbiotics was seriously compromised by the appearance of carbapenem-hydrolyzing enzymes called carbapenemases.
Bedenić, Branka, Sardelić, Sanda
openaire   +2 more sources

Spatiotemporal and genomic analysis of carbapenem resistance elements in Enterobacterales from hospital inpatients and natural water ecosystems of an Irish city

Microbiology Spectrum
Carbapenemase-producing Enterobacterales (CPE) is a diverse group of often multidrug-resistant organisms. Surveillance and control of infections are complicated due to the inter-species spread of carbapenemase-encoding genes (CEGs) on mobile genetic ...
Mark Maguire, Carlos Serna, Natalia Montero Serra, Aneta Kovarova, Louise O’Connor, Niamh Cahill, Brigid Hooban, Niall DeLappe, Wendy Brennan, Genevieve Devane, Martin Cormican, Dearbháile Morris, Simone C. Coughlan, Georgios Miliotis, Bruno Gonzalez-Zorn, Liam P. Burke   +15 more
doaj   +1 more source

The emergence of plasmid-encoded oxacillinase and carbapenemase among uropathogenic Escherichia coli (UPEC) isolated from hospitalized patients in the North of Iran

Heliyon, 2023
Carbapenemase enzyme production is responsible for resistance to carbapenem among Gram-negative bacteria. This study aimed to detect common carbapenemase and oxacilinase genes among uropathogenic E.
Mahsa Sadeghi, Ali Mojtahedi, Iraj Nikokar, Zahra Atrkar Roushan   +3 more
doaj   +1 more source

Paradoxical carbapenemase activity detected by modified carbapenemase inactivation (mCIM) method in Citrobacter sedlakii

Journal of Clinical Microbiology
Screening for carbapenemase-producing Enterobacterales is a necessity for hospitals serving high-risk patient populations. Detection methods often incorporate the modified carbapenemase inactivation method (mCIM) test to verify carbapenemase production ...
D. Garrett Brown, Matthew Surette, Sreejana Ray, Kevin Guo, Reagan Chan, Liusheng Huang, Sanchita Das   +6 more
doaj   +1 more source

Wide spread of carbapenemase-producing bacterial isolates in a Nigerian environment

Journal of Global Antimicrobial Resistance, 2020
Objectives: The presence of carbapenemase-producing bacterial isolates is found not only in hospital and community settings but also in the environment.
Christophe Le Terrier, Amandine Masseron, Nkolika Stella Uwaezuoke, Chinagozi P. Edwin, Agantem E. Ekuma, Folake Olugbeminiyi, Shuwaram Shettima, Simon Ushie, Laurent Poirel, Patrice Nordmann   +9 more
doaj   +1 more source

Klebsiella pneumoniaeCarbapenemase, Canada

Emerging Infectious Diseases, 2009
To the Editor: Carbapenems are used to treat life-threatening infections caused by extremely drug-resistant gram-negative pathogens; these drugs represent the last line of defense in the antimicrobial drug armamentarium against serious or invasive infection (1). The rapid global spread of Klebsiella pneumoniae that produces K. pneumoniae carbapenemase (
Dylan R. Pillai, Roberto G. Melano, Prasad Rawte, Stephen Lo, Nathalie Tijet, Milan Fuksa, Nancy Roda, David J. Farrell, Sigmund Krajden   +8 more
openaire   +2 more sources

In vitro activity of cefiderocol against carbapenemase-producing and meropenem-non-susceptible Gram-negative bacteria collected in the Japan Antimicrobial Resistant Bacterial Surveillance

Journal of Global Antimicrobial Resistance
Objectives: The treatment options available for infections caused by multidrug-resistant Gram-negative pathogens are often limited. Cefiderocol (CFDC) is a novel siderophore cephalosporin that exhibits activity against these pathogens.
Shizuo Kayama, Sayoko Kawakami, Kohei Kondo, Norikazu Kitamura, Liansheng Yu, Wataru Hayashi, Koji Yahara, Yo Sugawara, Motoyuki Sugai   +8 more
doaj   +1 more source

Novel Rapid Test for Detecting Carbapenemase [PDF]

Emerging Infectious Diseases, 2020
We developed a carbapenemase test based on the ability of imipenem to inhibit noncarbapenemase β-lactamases. The test uses bacterial isolates with a fluorescent β-lactamase substrate, producing objective results with 100% sensitivity and specificity in 10 minutes. The assay is inexpensive and consists of only 1 mixing step.
Yanfang Feng, Akilan Palanisami, Jerrin Kuriakose, Michael Pigula, Shoaib Ashraf, Tayyaba Hasan   +5 more
openaire   +3 more sources

Validation of Hexaplex Recombinase Polymerase Amplification Assay for the Detection of Carbapenemase Genes in Klebsiella pneumoniae Isolates From Pediatric Inpatients

Journal of Clinical Laboratory Analysis, EarlyView.
A novel hexaplex recombinase polymerase amplification (RPA) method was developed to rapidly and accurately detect five key carbapenemase genes and a Klebsiella pneumoniae‐specific target in a single reaction. This makes it an effective tool for CRKP detection in resource‐constrained environments.
Suthawan Mutitanon, Nuntaree Chaichanawongsaroj   +1 more
wiley   +1 more source

Point‐of‐Care Testing by Multiplex‐PCR in Different Compartments in Suspected Lower Respiratory Tract Infection After Lung Transplantation—Results of a Prospective Study

Transplant Infectious Disease, EarlyView.
Use of POCtmPCR with noninvasive samples (NPS and sputum) in LTx recipients with viral LRTI are a viable alternative to invasive BAL sampling, ABSTRACT Background Respiratory tract infections (RTIs) are a leading cause of morbidity and mortality following lung transplantation (LTx).
Susanne Simon, Merle Sophie Kaiser, Marcus Bachmann, Gérard Krause, Jens Gottlieb   +4 more
wiley   +1 more source