Results 151 to 160 of about 38,283 (181)

Cephalosporins to carbapenems: 1-oxygenated carbapenems and carbapenams

Journal of Medicinal Chemistry, 1990
The photo "Wolff" rearrangement of readily available 2-diazoceph-3-em oxides (1) directly affords carbapen-2-ems, allowing a facile entry into a ring system previously accessible only by total synthesis, lengthly semisynthesis or fermentation. The chirality of the cephalosporin is accurately translated into the corresponding carbapenem. The resulting 1-
R L, Rosati, L V, Kapili, P, Morrissey, J A, Retsema   +3 more
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Carbapenems and Penems

Obstetrics and Gynecology Clinics of North America, 1989
Carbapenems and penems are a unique class of antibiotics. These agents have a broad spectrum of activity, with activity against aerobic and anaerobic bacteria, often including bacteria possessing multiple resistant factors.
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Recent developments in carbapenems

Expert Opinion on Investigational Drugs, 2002
Carbapenems are beta-lactam antibiotics characterised by the presence of a beta-lactam ring with a carbon instead of sulfone in the 4-position of the thyazolidinic moiety. The first carbapenem to be utilised in therapy was imipenem, the N-formimidoyl derivative of thienamycin.
Giovanni, Bonfiglio, Giovanni, Russo, Giuseppe, Nicoletti   +2 more
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CEPHALOSPORINS, CARBAPENEMS, AND MONOBACTAMS

Infectious Disease Clinics of North America, 2000
Nonpenicillin beta-lactams exhibit a variable spectrum of antimicrobial activity, have a wide range of clinical uses and a favorable safety profile. Cefepime's twice-daily dosage and increased activity against Enterobacteriaceae may offer some advantages over older cephalosporins.
L E, Asbel, M E, Levison
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Carbapenem-based prodrugs. Design, synthesis, and biological evaluation of carbapenems

European Journal of Medicinal Chemistry, 2005
Syntheses of racemic trans-3-hydroxycarbonyl-6-(phenylacetamido)carbapenem (13), trans-3-phosphono-6-(phenylacetamido)carbapenem (17), and beta-lactam based prodrugs 19 and 22 were accomplished. Carbapenem 13 was found to possess antibacterial activity, comparable with imipenem (+)-3, against Staphylococcus aureus FDA 209P, S.
Gholam Hossein, Hakimelahi, Ali Akbar, Moosavi-Movahedi, Ali Akbar, Saboury, Valeriy, Osetrov, Ghadam Ali, Khodarahmi, Kak-Shan, Shia   +5 more
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Current Status of Newer Carbapenems

Current Medicinal Chemistry, 2009
Beta-lactam antibiotics represent the most commonly prescribed antibacterial agents. Since many bacteria have developed resistance to older agents, new beta-lactams have been introduced constantly. In the late 1970s, a new class of exceptionally broad-spectrum beta-lactams, the carbapenems, was identified.
BASSETTI M, NICOLINI, LAURA AMBRA, ESPOSITO S, RIGHI E, VISCOLI, CLAUDIO   +4 more
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A new carbapenem drug dosage metric for carbapenem usage and correlation with carbapenem resistance of Pseudomonas aeruginosa

Journal of Infection and Chemotherapy, 2018
The emergence and dissemination of antimicrobial resistance is a worldwide problem. Inappropriate antimicrobial use contributes to this resistance, and several metrics of drug usage have been used to monitor their consumption and rational use. We examined several existing drug metrics, and developed a new one, dose/duration-density (D/d2), for a the ...
Shinobu Hirayama, Kumiko Yasui, Hinako Murakami, Takayoshi Kosugi, Maki Sakamoto, Yuki Hanai, Kazuhiro Matsuo, Taito Miyazaki, Yoshikazu Ishii, Kenji Nishizawa, Kazuhiro Tateda   +10 more
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Ertapenem: a new carbapenem

Expert Opinion on Investigational Drugs, 2001
Ertapenem is a new 1-beta-methyl carbapenem, stable to dehydropeptidase, which binds preferable to penicillin-binding proteins (PBP) 2 and 3. Ertapenem has a broad antibacterial spectrum with MIC90 values < 0.5 mg/l for penicillin-susceptible Streptococcus pneumoniae, Streptococcus pyogenes, methicillin-sensitive Staphylococcus aureus, Haemophilus ...
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Neurotoxicity of Carbapenem Antibacterials

Drug Safety, 1996
Similar to other beta-lactam antibacterials, carbapenems have a neurotoxic potential that seems to be higher than that of the penicillins and cephalosporins. Seizures have been reported in several large studies of patients treated with imipenem/cilastatin.
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Carbapenems

Seminars in Pediatric Infectious Diseases, 2001
Katherine M. Knapp, B.Keith English
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