Results 61 to 70 of about 35,108 (280)

Engineered C–N Lyases for Stereoselective Synthesis of Tertiary Amines

Angewandte Chemie, EarlyView.
EDDS lyase was subjected to iterative cycles of site‐saturation mutagenesis and screened for increased activity for the addition of 2‐((methylamino)methyl)aniline to fumarate. The final mutant, EDDS lyase CEA, accepts various N‐methyl‐1‐phenylmethanamines derivatives, yielding N,N‐disubstituted L‐aspartic acids, as well as several ortho‐substituted ...
Laura Bothof, Xiaofang Gong, Marrit E. Onclin, Peter Fodran, Gerrit J. Poelarends   +4 more
wiley   +2 more sources

Piano‐Stool Rhodium(V) and Rhodium(IV) Intermediates in C─H Functionalization and B─H Functionalization: Mechanistic Insights and Emerging Reactivity

Asian Journal of Organic Chemistry, EarlyView.
High‐valent Rh(IV) and Rh(V) species have been invoked to rationalize enhanced catalytic reactivity. This review examines evidence for both, emphasizing reactions proceeding through the Rh(III)/Rh(IV)/Rh(II) cycle. While Rh(V) intermediates are computationally supported, experimental evidence is limited; Rh(IV) species are supported by both theory and ...
Yujie Cao, Arnav Kacker, Kevin G. M. Kou
wiley   +1 more source

Ligand‐Controlled Chemoselectivity in the Rhodium‐Catalyzed Synthesis of Pentafulvenes via (2 + 2 + 1) Alkyne Cyclotrimerization

Angewandte Chemie, EarlyView.
Chemoselectivity Challenge: A precise catalyst design allows for chemoselectivity control over alkyne reactivity to yield pentafulvenes via (2 + 2 + 1) cyclotrimerization. Operative mechanism has been elucidated by means of stoichiometric and deuteration experiments, as well as DFT calculations.
Belinda Español‐Sánchez, Jesús Moradell, María Galiana‐Cameo, Eduardo Barrenas, Jesús J. Pérez‐Torrente, Vincenzo Passarelli, Ricardo Castarlenas   +6 more
wiley   +2 more sources

Carbenes in Action [PDF]

Science, 2009
Chemists are taming a highly reactive class of molecules for use in catalysis and synthesis.
openaire   +4 more sources

Untersuchungen an mesoionischen Imin‐Carbodiimid (MII‐CDI) Addukten: 1,3 H‐Wanderung, N(I) Verbindungen und Guanidinat‐artige Liganden

Angewandte Chemie, EarlyView.
Wir demonstrieren die einzigartige Reaktivität eines mesoionischen Imins mit bis‐aryl Carbodiimiden unter der Bildung eines MII‐CDI Addukts bei Raumtemperatur nach spontaner 1,3‐H Wanderung. Diese MII‐CDI Addukte sind wichtige Synthons für mesoionische Carben‐acyclische Diaminocarben stabilisierte Nitreone (I) und guanidinatartige Liganden ...
Alok Mahata, Richard Rudolf, Robert R. M. Walter, Nicolás. I. Neuman, Biprajit Sarkar   +4 more
wiley   +1 more source

Deconstructive Radical–Radical Coupling for Programmable Remote Acylation

Angewandte Chemie, EarlyView.
A unified approach to access a variety of 1,n‐dicarbonyls through a radical‐promoted deconstructive process utilizing dual photocatalysis/carbene catalysis is reported. The utility of this strategy is demonstrated with a broad scope with robust functional group tolerance along with application in the preparation of γ‐amino esters, three‐component ...
Jing Cao, Cullen R. Schull, Karl A. Scheidt   +2 more
wiley   +2 more sources

Die Chemie und Biologie der Tetrodotoxin Naturstofffamilie

Angewandte Chemie, EarlyView.
Tetrodotoxin ist vor allem als das Gift des Kugelfisches bekannt, einer Delikatesse in der japanischen Küche. Seine Toxizität beruht auf der selektiven Blockade von NaV Kanälen, wie am Beispiel der NaV1.7 Pore dargestellt, wobei das DEKA Motiv hervorgehoben ist, das für die Durchlässigkeit von Natriumionen verantwortlich ist.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

Overcoming Challenges in Small‐Ring Transfer: Direct Decarboxylative Hydroalkylation of Alkenes via Iron‐Thiol Catalysis

Angewandte Chemie, EarlyView.
Herein, we present a catalytic approach for the direct decarboxylation of challenging CF3‐cyclopropyl and cyclobutyl carboxylic acids using cooperative iron‐thiol catalysis. This strategy enables the efficient generation of valuable radicals that can be incorporated into activated and unactivated alkenes, offering access to elusive chemical space ...
Rahul Giri, Po‐Kai Peng, Anthony J. Fernandes, Shijin Yu, Julian G. West, Dmitry Katayev   +5 more
wiley   +2 more sources

Bemerkenswerte Reaktivität eines 1,2‐Dihydrodialans mit organischen Aziden – vom terminalen Diazido–Dialuman zur pendeluhrartigen Azidbrücke

Angewandte Chemie, EarlyView.
Die Reaktion eines Dihydro‐Dialans, das von einem Hybridliganden (DNI) koordiniert wird, mit organischen Aziden ergibt strukturell unterschiedliche Aluminiumspezies mit Aluminium in niedriger Oxidationsstufe: das erste Diazido‐Dialan, ein Aluminium‐Tetrazol und Produkte der Azid‐Aluminierung.
Xiaobai Wang, Franziska Traeger, Raphael F. Ligorio, Nico Graw, Regine Herbst‐Irmer, Anna Krawczuk, Malte Fischer, Dietmar Stalke   +7 more
wiley   +1 more source

An Atomically Dispersed Photocatalyst for Undirected para‐Selective C─H Bond Functionalizations

Angewandte Chemie, EarlyView.
This study presents an atomically dispersed recyclable heterogeneous photocatalytic method for para‐selective trifluoromethylation of electron‐deficient arenes without directing groups. Unlike previous substrate‐dependent approaches, this recyclable, atomically dispersed photocatalyst enables scalable synthesis of bioactive trifluoromethylated ...
Suman Pradhan, Jun Hu, Peng Ren, Yuman Qin, Noopur Jain, Susanna Monti, Giovanni Barcaro, Aleksander Jaworski, Xingchao Dai, Jabor Rabeah, Joaquin Silvestre‐Albero, Veronica Celorrio, Anna Rokicińska, Piotr Kuśtrowski, Sandra Van Aert, Sara Bals, Shoubhik Das   +16 more
wiley   +2 more sources