Results 51 to 60 of about 4,087,047 (240)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The Gut Microbiome and Lignocellulose Digestion in Constrictotermes cyphergaster (Termitidae: Nasutitermitinae): A Termite Incorporating Lichen into Its Diet

Diversity
Lichen-feeding termites occupy a distinctive ecological niche. This feeding behavior underscores a complex interplay between the termites’ digestive abilities and the biochemical properties of lichens, known for their resilience and production of ...
Alberto Arab, Luciana Campos Paulino, Maria Socorro Lacerda Rolim, Letícia Ramos de Menezes, Mário Herculano de Oliveira, Renato Augusto Corrêa dos Santos, João Paulo Lourenço Franco Cairo, Maria Avany Bezerra-Gusmão, Ana Maria Costa-Leonardo, Hélida Cunha, David Sillam-Dussès   +10 more
doaj   +1 more source

Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme [PDF]

, 2012
The transketolase (TKT) enzyme in Mycobacterium tuberculosis represents a novel drug target for tuberculosis treatment and has low homology with the orthologous human enzyme.
Jones, T. Alwyn, Elizabeth Fullam, Cole, Stewart T., Stewart T. Cole, Jones, T Alwyn, Florence Pojer, Fullam, Elizabeth, Pojer, Florence, Bergfors, Terese, Fullam, E., Cole, Stewart T, Bergfors, T., T. Alwyn Jones, Jones, T. A., Terese Bergfors, Pojer, F., Cole, S. T., Jones, T. Alwyn,, Bergfors, Terese,   +18 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genome sequencing of gut symbiotic Bacillus velezensis LC1 for bioethanol production from bamboo shoots

Biotechnology for Biofuels, 2020
Background Bamboo, a lignocellulosic feedstock, is considered as a potentially excellent raw material and evaluated for lignocellulose degradation and bioethanol production, with a focus on using physical and chemical pre-treatment.
Yuanqiu Li, Lu Lei, Li Zheng, Ximeng Xiao, Hao Tang, Chaobing Luo   +5 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380 [PDF]

, 2006
Includes bibliographical references.Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin
Chitapi, Itai
core   +1 more source

Comparative genomics reveals carbohydrate enzymatic fluctuations and herbivorous adaptations in arthropods

Computational and Structural Biotechnology Journal
Background: Arthropods represent the largest and most diverse phylum on Earth, playing a pivotal role in the biosphere. One key to their evolutionary success is their ability to feed on plant material.
Dairon Ojeda-Martinez, Isabel Diaz, M. Estrella Santamaria, Félix Ortego   +3 more
doaj   +1 more source