Results 61 to 70 of about 219,419 (292)

Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme [PDF]

, 2012
The transketolase (TKT) enzyme in Mycobacterium tuberculosis represents a novel drug target for tuberculosis treatment and has low homology with the orthologous human enzyme.
Jones, T. Alwyn, Elizabeth Fullam, Cole, Stewart T., Stewart T. Cole, Jones, T Alwyn, Florence Pojer, Fullam, Elizabeth, Pojer, Florence, Bergfors, Terese, Fullam, E., Cole, Stewart T, Bergfors, T., T. Alwyn Jones, Jones, T. A., Terese Bergfors, Pojer, F., Cole, S. T., Jones, T. Alwyn,, Bergfors, Terese,   +18 more
core   +1 more source

Carbohydrate-Active Enzymes: Structure, Activity, and Reaction Products [PDF]

International Journal of Molecular Sciences, 2020
Carbohydrate-active enzymes are responsible for both the biosynthesis and breakdown of carbohydrates and glycoconjugates [...]
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Astroenzymology – the environmental limits of enzyme activity

, 2003
Using organisms from extreme terrestrial environments as models for extraterrestrial life may lead us to underestimate the range of environments that life may inhabit.
Daniel, Roy M., Roy Daniel
core   +1 more source

The Gut Microbiome and Lignocellulose Digestion in Constrictotermes cyphergaster (Termitidae: Nasutitermitinae): A Termite Incorporating Lichen into Its Diet

Diversity
Lichen-feeding termites occupy a distinctive ecological niche. This feeding behavior underscores a complex interplay between the termites’ digestive abilities and the biochemical properties of lichens, known for their resilience and production of ...
Alberto Arab, Luciana Campos Paulino, Maria Socorro Lacerda Rolim, Letícia Ramos de Menezes, Mário Herculano de Oliveira, Renato Augusto Corrêa dos Santos, João Paulo Lourenço Franco Cairo, Maria Avany Bezerra-Gusmão, Ana Maria Costa-Leonardo, Hélida Cunha, David Sillam-Dussès   +10 more
doaj   +1 more source

Metatranscriptomics Unravel Composition, Drivers, and Functions of the Active Microorganisms in Light-Flavor Liquor Fermentation

Microbiology Spectrum, 2022
The microbial community in the fermented pit determines the quantity and quality of light-flavor liquor. Genetic diversity and the potential functions of the microbial community are often analyzed by DNA-based omics sequencing.
Yuanyuan Pan, Ying Wang, Wenjun Hao, Chengbao Duan, Shiyuan Wang, Jinwang Wei, Gang Liu   +6 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The angiotensin-converting enzyme (ACE) gene family of Anopheles gambiae [PDF]

, 2005
Background Members of the M2 family of peptidases, related to mammalian angiotensin converting enzyme (ACE), play important roles in regulating a number of physiological processes.
Lee, A.J., Smith Judith A, Lee, Alison J., Shirras Alan D, Shirras, A.D., Smith, Judith A., Isaac, R.E., Shirras, Alan D., Isaac R Elwyn, Burnham Susan, Smith, J.A., Burnham, Susan, Burnham, S., Lee Alison J, Isaac, R. Elwyn   +14 more
core   +1 more source

Genome sequencing of gut symbiotic Bacillus velezensis LC1 for bioethanol production from bamboo shoots

Biotechnology for Biofuels, 2020
Background Bamboo, a lignocellulosic feedstock, is considered as a potentially excellent raw material and evaluated for lignocellulose degradation and bioethanol production, with a focus on using physical and chemical pre-treatment.
Yuanqiu Li, Lu Lei, Li Zheng, Ximeng Xiao, Hao Tang, Chaobing Luo   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source