Results 1 to 10 of about 2,014 (128)

Protein flexibility drives sugar rotation and high substrate promiscuity in a GDP-sugar 4-epimerase [PDF]

Computational and Structural Biotechnology Journal
UDP-galactose 4-epimerases (Gal4Es) catalyze the inversion of the 4-hydroxyl configuration of a sugar moiety from an NDP-sugar through a three-step process: oxidation, rotation and reduction. Despite extensive biochemical and structural studies, the role
Carlos Josué Alvarez Quispe, Koen Beerens, Andy-Mark W.H. Thunnissen, Xevi Biarnés, Antoni Planas, Tom Desmet   +5 more
doaj   +5 more sources

Computational modeling of the molecular basis for the calcium-dependence of the mannuronan C-5 epimerase AvAlgE6 from Azotobacter vinelandii [PDF]

Computational and Structural Biotechnology Journal, 2023
The mannuronan C-5 epimerases catalyze epimerization of β-d-mannuronic acid to α-l-guluronic acid in alginate polymers. The seven extracellular Azotobacter vinelandii epimerases (AvAlgE1–7) are calcium-dependent, and calcium is essential for the ...
Margrethe Gaardløs, Anders Lervik, Sergey A. Samsonov   +2 more
doaj   +2 more sources

Carbohydrate utilization in Streptococcus thermophilus: characterization of the genes for aldose 1-epimerase (mutarotase) and UDPglucose 4-epimerase [PDF]

Journal of Bacteriology, 1990
The complete nucleotide sequences of the genes encoding aldose 1-epimerase (mutarotase) (galM) and UDPglucose 4-epimerase (galE) and flanking regions of Streptococcus thermophilus have been determined. Both genes are located immediately upstream of the S. thermophilus lac operon.
Poolman, Bert, Royer, Theresa J., Mainzer, Stanley E., Schmidt, Brian F.   +3 more
openaire   +5 more sources

RmlC, a C3′ and C5′ Carbohydrate Epimerase, Appears to Operate via an Intermediate with an Unusual Twist Boat Conformation [PDF]

Journal of Molecular Biology, 2007
The striking feature of carbohydrates is their constitutional, conformational and configurational diversity. Biology has harnessed this diversity and manipulates carbohydrate residues in a variety of ways, one of which is epimerization. RmlC catalyzes the epimerization of the C3' and C5' positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-
Dong, Changjiang, Major, Louise L, Srikannathasan, Velupillai, Errey, James C, Giraud, Marie-France, Lam, Joseph S, Graninger, Michael, Messner, Paul, McNeil, Michael R, Field, Robert A, Whitfield, Chris, Naismith, James H   +11 more
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The role of UDP‐glucose epimerase in carbohydrate metabolism of Arabidopsis [PDF]

The Plant Journal, 1998
SummaryUridine 5′‐diphospho‐glucose‐4‐epimerase (UDP‐Glc epimerase) catalyses the reversible epimerization of UDP‐galactose and UDP‐glucose. In contrast to bacteria and yeast, expression of the UDP‐Glc epimerase gene in Arabidopsis was found not to be induced by galactose.
P, Dörmann, C, Benning
openaire   +3 more sources

Functional Characterization of the Rice UDP-glucose 4-epimerase 1, OsUGE1: A Potential Role in Cell Wall Carbohydrate Partitioning during Limiting Nitrogen Conditions

PLoS ONE, 2014
Plants grown under inadequate mineralized nitrogen (N) levels undergo N and carbon (C) metabolic re-programming which leads to significant changes in both soluble and insoluble carbohydrate profiles. However, relatively little information is available on the genetic factors controlling carbohydrate partitioning during adaptation to N-limitation ...
David R Guevara, Ashraf El-Kereamy, Mahmoud W Yaish, Yong Mei-Bi, Steven J Rothstein   +4 more
openaire   +5 more sources

Catalysis, Structures, and Applications of Carbohydrate Epimerases

Journal of Applied Glycoscience, 2010
Susumu Ito
openaire   +3 more sources

D-galactose catabolism in Penicillium chrysogenum: Expression analysis of the structural genes of the Leloir pathway [PDF]

, 2016
In this study, we analyzed the expression of the structural genes encoding the five enzymes comprising the Leloir pathway of D-galactose catabolism in the industrial cell factory Penicillium chrysogenum on various carbon sources.
Fekete, Erzsébet, Flipphi, Michel, Jónás, Ágota, Karaffa, Levente, Németh, Zoltán   +4 more
core   +4 more sources

Mannuronate C-5 epimerases and their use in alginate modification [PDF]

, 2023
Alginate is a polysaccharide consisting of β-D-mannuronate (M) and α-L-guluronate (G) produced by brown algae and some bacterial species. Alginate has a wide range of industrial and pharmaceutical applications, owing mainly to its gelling and ...
Aachmann, Finn Lillelund, Beenfeldt Petersen, Agnes, Ertesvåg, Helga, Gaardløs, Margrethe, Sletta, Håvard, Tøndervik, Anne   +5 more
core   +1 more source

Sn-Beta zeolites with borate salts catalyse the epimerization of carbohydrates via an intramolecular carbon shift [PDF]

, 2012
Carbohydrate epimerization is an essential technology for the widespread production of rare sugars. In contrast to other enzymes, most epimerases are only active on sugars substituted with phosphate or nucleotide groups, thus drastically restricting ...
A Corma, A Corma, A Corma, A Eschenmoser, A Huwig, A Köckritz, A Pines, AE Bennett, CR Morcombe, F de Clippel, G Gumina, H-J Kim, JB Lambert, L Du, L Li, L Petruš, M Boronat, M Moliner, M Renz, MA Hossain, MML Hayes, MS Holm, MS Holm, NK Mal, PJ Bray, PP Pescarmona, R Bermejo-Deval, R Huang, R Smoum, R Stockman, R van den Berg, RK Harris, S Angyal, S Zhao, SA Benner, SJ Angyal, STM Allard, T Tanase, TB Granström, TE Walker, V Bílik, VK Michaelis, VN Sagi, Y Lu, Y Román-Leshkov, Y Román-Leshkov   +45 more
core   +1 more source