Results 41 to 50 of about 2,014 (128)
TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models
The FEBS Journal, Volume 293, Issue 2, Page 348-384, January 2026.The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir +7 more
wiley +1 more source
Quorum sensing for improved production of industrially useful products from filamentous fungi [PDF]
, 2014 Quorum sensing (QS) is a cell density dependant phenomena utilized as a communication process among microorganisms to regulate their physiological responses. QS depends on the production and release of low molecular weight, diffusible chemical signalling
Amache, R., Amache, R.
core
Plant Biotechnology Journal, Volume 24, Issue 1, Page 239-255, January 2026.Summary Nicotiana benthamiana serves as a unique platform for biopharmaceutical production, offering advantages such as efficient and scalable protein synthesis. In addition, custom N‐glycans can be engineered on biopharmaceutical glycoproteins. Yet, plant‐native glycosyltransferases and glycoside hydrolases need to be removed to prevent undesired ...
Lukas C. Blumberg +8 more
wiley +1 more source
NMR assignments of 1H, 13C and 15N resonances of the C-terminal subunit from Azotobacter vinelandii mannuronan C5-epimerase 6 (AlgE6R3) [PDF]
, 2010 The 19.9 kDa C-terminal module (R3) from Azotobacter vinelandii mannronan C5-epimerase AlgE6 has been 13C, 15N isotopically labelled and recombinantly expressed.
C Campa +13 more
core +2 more sources
Posttranslational modifications of heterologous proteins expressed in Nicotiana benthamiana
Plant Biotechnology Journal, Volume 24, Issue 1, Page 44-54, January 2026.Summary The success of Nicotiana benthamiana as a workhorse for heterologous protein production is closely linked to its accessibility and tolerance to genetic manipulation, allowing efficient engineering of posttranslational protein modifications (PTMs) that are critical for the function and stability of heterologous proteins.
Kathrin Göritzer +2 more
wiley +1 more source
Evolution of Plant Nucleotide-Sugar Interconversion Enzymes [PDF]
, 2011 Nucleotide-diphospho-sugars (NDP-sugars) are the building blocks of diverse polysaccharides and glycoconjugates in all organisms. In plants, 11 families of NDP-sugar interconversion enzymes (NSEs) have been identified, each of which interconverts one NDP-
Bar-Peled, Maor +4 more
core +8 more sources
In-process epimerisation of alginates from Saccharina latissima, Alaria esculenta and Laminaria hyperborea [PDF]
Alginates are valued in many industries, due to their versatile properties. These polysaccharides originate from brown algae (Phaeophyceae) and some bacteria of the Azotobacter and Pseudomonas genera, consisting of 1 → 4 linked β-d-mannuronic acid (M ...
Aachmann, Finn Lillelund +4 more
core +1 more source
Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes
FEBS Letters, Volume 599, Issue 23, Page 3417-3443, December 2025.Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley +1 more source
Advanced Science, Volume 12, Issue 47, December 18, 2025.A genome‐scale model guided the systematic metabolic engineering of Saccharopolyspora spinosa, enabling a 5.5‐fold boost in the green bioinsecticide spinosad to 1.8 g L−1 and establishing an actinomycete framework for complex natural products overproduction.
Shuliu Wang +9 more
wiley +1 more source
Molecular characterization and optimization of enzymes involved in glycosaminoglycan biosynthesis [PDF]
, 2011 Glycosaminoglycans are biological active polysaccharides composed of repeating disaccharides composed of a hexuronic acid and a hexosamine. They have various pharmaceutical applications and traditionally this type of molecule is isolated from animal ...
Raedts, J.G.J.
core +1 more source