Results 51 to 60 of about 11,416 (241)

Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma

Cancer Medicine, 2018
Carbon ion radiotherapy is known for its high‐precision dose distribution and high biological effectiveness. We evaluated the results of carbon ion radiotherapy in 128 patients with unresectable localized axial soft tissue sarcoma at a single institution.
Reiko Imai, Tadashi Kamada, Nobuhito Araki, and the Working Group for Carbon Ion Radiotherapy for Bone and Soft Tissue Sarcomas   +3 more
doaj   +1 more source

Carbon ion radiotherapy for basal cell adenocarcinoma of the head and neck: preliminary report of six cases and review of the literature

Radiation Oncology, 2010
Background Basal cell adenocarcinoma accounts for approximately 1.6% of all salivary gland neoplasms. In this report, we describe our experiences of treatment for BCAC with carbon ion radiotherapy in our institution.
Tsuji Hiroshi, Morikawa Takamichi, Bessho Hiroki, Mizo Jun-Etsu, Hasegawa Azusa, Jingu Keiichi, Tsujii Hirohiko, Kamada Tadashi   +7 more
doaj   +1 more source

Carbon Ion Radiotherapy for Unresectable Sacral Chordomas [PDF]

Clinical Cancer Research, 2004
Abstract Purpose: The purpose is to evaluate the efficacy and toxicity of carbon ion radiotherapy for unresectable sacral chordomas. Experimental Design: We performed a retrospective analysis of 30 patients with unresectable sacral chordomas treated with carbon ion radiotherapy at the Heavy Ion Medical Accelerator in Chiba,
Reiko, Imai, Tadashi, Kamada, Hiroshi, Tsuji, Takeshi, Yanagi, Masayuki, Baba, Tadaaki, Miyamoto, Shingo, Kato, Susumu, Kandatsu, Jun-etsu, Mizoe, Hirohiko, Tsujii, Shin-ichiro, Tatezaki   +10 more
openaire   +2 more sources

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Clinical Results of Carbon Ion Radiotherapy at NIRS [PDF]

Journal of Radiation Research, 2007
In 1994 a Phase I/II clinical study on carbon ion radiotherapy was begun at NIRS using HIMAC, which was then the world's only heavy ion accelerator complex dedicated to medical use in a hospital environment. Among several types of ion species, we have chosen carbon ions for cancer therapy because they had the most optimal properties in terms of ...
Hirohiko, Tsujii, Junetsu, Mizoe, Tadashi, Kamada, Masayuki, Baba, Hiroshi, Tsuji, Hirotoshi, Kato, Shingo, Kato, Shigeru, Yamada, Shigeo, Yasuda, Tatsuya, Ohno, Takeshi, Yanagi, Reiko, Imai, Kenji, Kagei, Hiroyuki, Kato, Ryusuke, Hara, Azusa, Hasegawa, Mio, Nakajima, Norio, Sugane, Noriaki, Tamaki, Ryo, Takagi, Susumu, Kandatsu, Kyosan, Yoshikawa, Riwa, Kishimoto, Tadaaki, Miyamoto   +23 more
openaire   +2 more sources

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation

Nanoscale Research Letters, 2019
Gadolinium-based nanomaterials can not only serve as contrast agents but also contribute to sensitization in the radiotherapy of cancers. Among radiotherapies, carbon ion irradiation is considered one of the superior approaches with unique physical and ...
Feifei Li, Zihou Li, Xiaodong Jin, Yan Liu, Ping Li, Zheyu Shen, Aiguo Wu, Xiaogang Zheng, Weiqiang Chen, Qiang Li   +9 more
doaj   +1 more source

Benchmarking of FLUKA production cross sections of positron emission tomography isotopes for in-vivo range verification in hadron therapy [PDF]

EPJ Web of Conferences, 2020
Protons and carbon ions have been extensively used for radiotherapy treatments, and in comparison to conventional radiotherapy, they allow a more conformal dose to the target tumor, especially in case of deep-seated tumors.
Aricò Giulia, Battistoni Giuseppe, Cerutti Francesco, Horst Felix, Mairani Andrea, Schuy Christoph, Weber Uli, Ferrari Alfredo   +7 more
doaj   +1 more source

A Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy

Advanced Science, EarlyView.
An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu, Peng Li, Zhixiang Lu, Shuqin Xu, Juanjuan Wang, Kai Ma, Haodong Yu, Can Zhou, Hu Chen, Gang Liu, Yi Lyu, Shuang Bai   +11 more
wiley   +1 more source