Results 61 to 70 of about 28,950 (250)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dosimetric impact of stopping power for human bone porosity with dual-energy computed tomography in scanned carbon-ion therapy treatment planning

Scientific Reports
Few reports have documented how the accuracy of stopping power ratio (SPR) prediction for porous bone tissue affects the dose distribution of scanned carbon-ion beam therapy.
Masashi Yagi, Yushi Wakisaka, Jun Takeno, Shintaro Kanada, Toshiro Tsubouchi, Noriaki Hamatani, Hiroyasu Maruo, Masaaki Takashina, Takayoshi Ishii, Tatsuaki Kanai, Shinichi Shimizu, Kazuhiko Ogawa   +11 more
doaj   +1 more source

Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma

Cancer Medicine, 2018
Carbon ion radiotherapy is known for its high‐precision dose distribution and high biological effectiveness. We evaluated the results of carbon ion radiotherapy in 128 patients with unresectable localized axial soft tissue sarcoma at a single institution.
Reiko Imai, Tadashi Kamada, Nobuhito Araki, and the Working Group for Carbon Ion Radiotherapy for Bone and Soft Tissue Sarcomas   +3 more
doaj   +1 more source

Carbon ion radiotherapy for basal cell adenocarcinoma of the head and neck: preliminary report of six cases and review of the literature

Radiation Oncology, 2010
Background Basal cell adenocarcinoma accounts for approximately 1.6% of all salivary gland neoplasms. In this report, we describe our experiences of treatment for BCAC with carbon ion radiotherapy in our institution.
Tsuji Hiroshi, Morikawa Takamichi, Bessho Hiroki, Mizo Jun-Etsu, Hasegawa Azusa, Jingu Keiichi, Tsujii Hirohiko, Kamada Tadashi   +7 more
doaj   +1 more source

Combined treatment of malignant salivary gland tumours with intensity-modulated radiation therapy (IMRT) and carbon ions: COSMIC [PDF]

, 2010
Background Local control in malignant salivary gland tumours is dose dependent. High local control rates in adenoid cystic carcinomas could be achieved by highly conformal radiotherapy techniques and particle (neutron/carbon ion) therapy.
Alexandra D Jensen, Anna Nikoghosyan, Christine Windemuth-Kieselbach, Jürgen Debus, Marc W Münter   +4 more
core   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Nanolesions induced by heavy ions in human tissues: experimental and theoretical studies [PDF]

, 2012
The biological effects of energetic heavy ions are attracting increasing interest for their applications in cancer therapy and protection against space radiation.
Cathrin Wälzlein, Francesco Natale, Gisela Taucher-scholz, Igor Mishustin, Igor Pshenichnov, Iris Müller, Lucas Burigo, M. Huth, Marco Durante, Marcus Bleicher, Maren Herrlitz, Michael Krämer, Stefan Schramm   +12 more
core   +2 more sources

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation

Nanoscale Research Letters, 2019
Gadolinium-based nanomaterials can not only serve as contrast agents but also contribute to sensitization in the radiotherapy of cancers. Among radiotherapies, carbon ion irradiation is considered one of the superior approaches with unique physical and ...
Feifei Li, Zihou Li, Xiaodong Jin, Yan Liu, Ping Li, Zheyu Shen, Aiguo Wu, Xiaogang Zheng, Weiqiang Chen, Qiang Li   +9 more
doaj   +1 more source

Biodamage via shock waves initiated by irradiation with ions [PDF]

, 2013
Radiation damage following the ionising radiation of tissue has different scenarios and mechanisms depending on the projectiles or radiation modality. We investigate the radiation damage effects due to shock waves produced by ions.
Solov'yov, Andrey V., Surdutovich, Eugene, Yakubovich, Alexander V.   +2 more
core   +1 more source