Results 81 to 90 of about 28,950 (250)

Development and characterization of a dedicated dose monitor for ultrahigh-dose-rate scanned carbon-ion beams

Scientific Reports
The current monochromatic beam mode (i.e., uHDR irradiation mode) of the scanned carbon-ion beam lacks a dedicated dose monitor, making the beam control challenging.
Masashi Yagi, Shinichi Shimizu, Noriaki Hamatani, Takuto Miyoshi, Takuya Nomura, Takashi Toyoda, Mahoro Nakatani, Toshiro Tsubouchi, Masaki Shimizu, Yoshiaki Kuwana, Masumi Umezawa, Masaaki Takashina, Teiji Nishio, Masahiko Koizumi, Kazuhiko Ogawa, Tatsuaki Kanai   +15 more
doaj   +1 more source

In vitro evaluation of photon and carbon ion radiotherapy in combination with chemotherapy in glioblastoma cells

Radiation Oncology, 2012
Background To evaluate the cytotoxic effect of carbon ion radiotherapy and chemotherapy in glioblastoma cells in vitro. Methods and Materials The human glioblastoma (GBM) cell line U87 was irradiated with photon radiotherapy (RT) doses of 2 Gy, 4 Gy and ...
Combs Stephanie E, Zipp Lisa, Rieken Stefan, Habermehl Daniel, Brons Stefan, Winter Marcus, Haberer Thomas, Debus Jürgen, Weber Klaus-Josef   +8 more
doaj   +1 more source

National Effort to Re-Establish Heavy Ion Cancer Therapy in the United States

Frontiers in Oncology, 2022
In this review, we attempt to make a case for the establishment of a limited number of heavy ion cancer research and treatment facilities in the United States.
Arnold Pompos, Robert L. Foote, Albert C. Koong, Quynh Thu Le, Radhe Mohan, Harald Paganetti, Hak Choy   +6 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

The Far Side of Carboranes: Anticancer Active Monocations and Ambiently Stable Dications

Angewandte Chemie, EarlyView.
This work describes the synthesis of bench‐stable dicationic carboranes. Their enhanced electrophilicity is documented by opening the clusters with weak nucleophiles or dihydrogen. The surprising stability of positively charged carboranes in water enabled a study of their in vitro antiproliferative activity, which surpassed the effects of doxorubicin ...
Vlastimil Němec, Josef Holub, Maksim A. Samsonov, Zdeňka Růžičková, Josef Cvačka, Ján Vančo, Zdeněk Trávníček, Jan Belza, Zdeněk Dvořák, Jan Vrána, Aleš Růžička   +10 more
wiley   +2 more sources

Efficacy and Safety of 4 Fractions of Carbon-Ion Radiation Therapy for Hepatocellular Carcinoma: A Prospective Study

Liver Cancer, 2021
Introduction: Prospective evidence supporting the safety and efficacy of carbon-ion radiotherapy (C-ion RT) for hepatocellular carcinoma (HCC) remains lacking.
Kei Shibuya, Hiroyuki Katoh, Yoshinori Koyama, Shintaro Shiba, Masahiko Okamoto, Shohei Okazaki, Kenichiro Araki, Satoru Kakizaki, Ken Shirabe, Tatsuya Ohno   +9 more
doaj   +1 more source

Tutorial on Neutron Physics in Dosimetry

, 2009
Almost since the time of the discovery of the neutron more than 70 years ago, efforts have been made to understand the effects of neutron radiation on tissue and, eventually, to use neutrons for cancer treatment. In contrast to charged particle or photon
Abrosimov, Bensussan, Blideanu, Blomgren, Borcea, Chadwick, Chadwick, Dyer, Henriksson, ICRU Report 63, Koning, Koning, Krane, Lebreton, Nolte, Pomp, Prokofiev, Rochman, S. Pomp, Soppera, Tanimura, Tippawan, Tippawan, Tippawan, Tubiana   +24 more
core   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Tumor control probability analysis for single fraction carbon ion radiotherapy of early-stage non-small cell lung cancer [PDF]

, 2018
学位記番号 ...
Athena Evalour, Simbahon Paz
core  

Design Study of a Superconducting Gantry for Carbon Beam Therapy

, 2016
This paper describes the design study of a gantry for a carbon beam. The designed gantry is compact such that its size is comparable to the size of the proton gantry. This is possible by introducing superconducting double helical coils for dipole magnets.
Kim, J., Yoon, M.
core   +1 more source