Results 61 to 70 of about 10,882 (190)

Enhanced Natamycin production by Streptomyces natalensis in shake-flasks and stirred tank bioreactor under batch and fed-batch conditions

BMC Biotechnology, 2019
Background Natamycin is an antifungal polyene macrolide antibiotic with wide applications in health and food industries. Currently, it is the only antifungal food additive with the GRAS status (Generally Regarded as Safe).
Elsayed Ahmed Elsayed, Mohamed A. Farid, Hesham A. El-Enshasy   +2 more
doaj   +1 more source

Evaluation of carbon:nitrogen ratio in semi-defined culture medium to tacrolimus biosynthesis by Streptomyces tsukubaensis and the effect on bacterial growth

Biotechnology Reports, 2020
Tacrolimus is an immunosuppressant produced by several Streptomyces species, widely used in transplantolgy and dermatology. In this report, attempts have been made to enhance tacrolimus productivity by altering the primary carbon source on culture media.
Jean Vinícius Moreira, Seforah Carolina Marques Silva, Marco Aurélio Cremasco   +2 more
doaj   +1 more source

Working So Hard: Double‐Stranded RNAs That Can Perform Both Gene Activation and Gene Silencing

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Working so hard: STING saRNAs are capable of not only entering the nucleus to induce subsequent target gene upregulation, but can also act as an siRNA to perform gene silencing. Chemical modifications in saRNA guide and passenger strands affect the strength of gene activation or gene silencing activity.
Virginia Wing‐Nam Chiu, Matthew Lawrence Hammill, Marwah Elabed, Sierra Varley, Yulia Lomonosova, Joseph Hoare, Jon Voutila, Henrik Hansen, Troels Koch, Jean‐Paul Desaulniers   +9 more
wiley   +1 more source

Small RNA as global regulator of carbon catabolite repression in Pseudomonas aeruginosa

, 2009
In the metabolically versatile bacterium Pseudomonas aeruginosa, the RNA-binding protein Crc is involved in catabolite repression of a range of degradative genes, such as amiE (encoding aliphatic amidase).
E. Sonnleitner, Sonnleitner, E., Haas, D., D. Haas, L. Abdou, Abdou, L.   +5 more
core   +1 more source

Thermodynamic Evaluation of Dual Substrate Growth

Biotechnology and Bioengineering, Volume 123, Issue 7, Page 1825-1835, July 2026.
ABSTRACT Various C₁–C₂ compounds are increasingly available through electrochemical reduction of CO2. Although not always suitable as a sole substrate, these compounds can supplement a primary substrate like glucose to enhance microbial growth. Yet, the mechanisms underlying the effects of dual substrate consumption on growth rate and growth yield ...
Marit A. Verheijen, Tim Meyboom, Mark C. M. van Loosdrecht, Rebeca Gonzalez‐Cabaleiro   +3 more
wiley   +1 more source

Overcome of carbon catabolite repression of bioinsecticides production by sporeless Bacillus thuringiensis through adequate fermentation technology [PDF]

, 2014
The overcoming of catabolite repression, in bioinsecticides production by sporeless Bacillus thuringiensisstrain S22 was investigated into fully controlled 3 L fermenter, using glucose based medium.
Khedher, Saoussen Ben, Zouari, Nabil, Jaoua, Samir   +2 more
core   +1 more source

Targeting of Staphyloxanthin and α‐Hemolysin by Natural Compound L‐Malic Acid Suppresses Staphylococcus aureus Virulence

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
L‐malic acid, a natural TCA cycle intermediate, attenuates the virulence of Staphylococcus aureus through dual metabolic and regulatory mechanisms. It redirects central carbon flux away from the mevalonate pathway and inhibits the key enzyme CrtO, suppressing staphyloxanthin biosynthesis and impairing bacterial resistance to oxidative stress ...
Li Shen, Bingjie Wang, Jinjin Yang, Xinru Yuan, Zhixuan Chen, Can Yang, Jiana Fu, Haojin Gao, Weihua Han, Junhong Shi, Fangyou Yu, Jingyi Yu   +11 more
wiley   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, Volume 600, Issue 12, Page 1729-1743, June 2026.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

The effect catabolite repression on a known secondary netabolite streptonycete [PDF]

, 1986
The possible involvement of carbon catabolite repression in control of synthesis of the polyether antibiotic M139603 was examined by culturing the producing organism S. Longisooroflavus in a variety of media containing a range of different carbon sources
P. Milner,
core  

Xylose and some non-sugar carbon sources cause catabolite repression in Saccharomyces cerevisiae

, 2022
Glucose and other sugars, such as galactose or maltose, are able to cause carbon catabolite repression in Saccharomyces cerevisiae. Although glycolytic intermediates have been suggested as signal for repression, no evidence for such a control mechanism ...
Gancedo, Juana M., Belinchón, Mónica M.   +1 more
core   +1 more source