Results 41 to 50 of about 1,386,588 (292)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Spatial differentiation characteristics and controlling factors of the epikarst thickness in Southwest China

Geoderma
The epikarst, a critical link between surface and subsurface in karst regions, plays a vital role in regulating groundwater cycle, sustaining biogeochemical cycles, and securing water resources.
Jinke Chen, Jianhong Li, Tao Zhang, Peng Chen, Shengxin Peng, Xinyu Kang, Xinlu Su, Wenqing Feng, Yaru Jiang, Alena Gessert, Nataša Ravbar, Eko Haryono, Junbing Pu   +12 more
doaj   +1 more source

Influence of cell cycle phase on calcification in the coccolithophore Emiliania huxleyi [PDF]

, 2008
Calcification of the cosmopolitan coccolithophore species Emiliania huxleyi was investigated in relation to the cell division cycle with the use of batch cultures.
Antia, Avan, LaRoche, Julie, Müller, Marius   +2 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Carbon-ammonia pairs for adsorption refrigeration applications : ice making, air conditioning and heat pumping [PDF]

, 2009
A thermodynamic cycle model is used to select an optimum adsorbent-refrigerant pair in respect of a chosen figure of merit that could be the cooling production (MJ m(-3)), the heating production (MJ m(-3)) or the coefficient of performance (COP).
Critoph, Robert E., Metcalf, Steven J., Tamainot-Telto, Zacharie, Thorpe, Roger, Zhong, Y.   +4 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Evaluation and optimization of enhanced coagulation process: Water and energy nexus

Water-Energy Nexus, 2019
The rapid deterioration of water quality poses a serious threat and at the same time giving rise to an opportunity to the researchers for solving the problem cogently through innovative coagulation strategies.
Yongjun Sun, Shengbao Zhou, Pen-Chi Chiang, Kinjal J. Shah   +3 more
doaj   +1 more source

Climate-dependent CO2 emissions from lakes [PDF]

, 2010
Inland waters, just as the world's oceans, play an important role in the global carbon cycle. While lakes and reservoirs typically emit CO2, they also bury carbon in their sediment.
Cole, J.J., Kosten, S., Mazzeo, N., Motta Marques, D.M.L., Da, Nes, E.H., van, Roland, F., Scheffer, M., Sternberg, L.S.L.   +7 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A long-term high-resolution dataset of grasslands grazing intensity in China

Scientific Data
Grazing is a significant anthropogenic disturbance to grasslands, impacting their function and composition, and affecting carbon budgets and greenhouse gas emissions.
Daju Wang, Qiongyan Peng, Xiangqian Li, Wen Zhang, Xiaosheng Xia, Zhangcai Qin, Peiyang Ren, Shunlin Liang, Wenping Yuan   +8 more
doaj   +1 more source