Results 41 to 50 of about 5,683,596 (347)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Evaluation and optimization of enhanced coagulation process: Water and energy nexus

Water-Energy Nexus, 2019
The rapid deterioration of water quality poses a serious threat and at the same time giving rise to an opportunity to the researchers for solving the problem cogently through innovative coagulation strategies.
Yongjun Sun, Shengbao Zhou, Pen-Chi Chiang, Kinjal J. Shah   +3 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Responses of soil detachment capacity to different rock dip angles in karst trough valley

Geoderma
The karst region is distinguished by pronounced and complex soil erosion, while the bedrock strata dip and root traits significantly influence the erosion slope, thereby altering the hydrodynamic characteristics and impacting Dc.
Lisha Jiang, Fengling Gan, Xiaohong Tan, Hailong Shi, Youjin Yan, Qiuhao Liao, Junbing Pu   +6 more
doaj   +1 more source

Sensitivity Analysis of Carbonate Looping Process Using Twin Fluidized Bed Model

Aerosol and Air Quality Research, 2020
CO2 as the major greenhouse gas plays an important role in environmental problems. Therefore, it is reasonable to find an effective technology for mitigating large CO2 emissions.
Xuan Yang, Yishu Qiao, Xiangyang Han, Bingcheng Liu, Kinjal J. Shah, Pen-Chi Chiang   +5 more
doaj   +1 more source

Applicability of Clay/Organic Clay to Environmental Pollutants: Green Way—An Overview

Applied Sciences, 2023
Natural clay mineral and its modifier called modified clay have been used in many environmental applications for a number of years. However, they are not capable enough to achieve a higher conversion rate and so-called ecological sustainability. This can
Jingfan Qi, Jiacheng Yu, Kinjal J. Shah, Dhirpal D. Shah, Zhaoyang You   +4 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A long-term high-resolution dataset of grasslands grazing intensity in China

Scientific Data
Grazing is a significant anthropogenic disturbance to grasslands, impacting their function and composition, and affecting carbon budgets and greenhouse gas emissions.
Daju Wang, Qiongyan Peng, Xiangqian Li, Wen Zhang, Xiaosheng Xia, Zhangcai Qin, Peiyang Ren, Shunlin Liang, Wenping Yuan   +8 more
doaj   +1 more source

Using Atmospheric Inverse Modelling of Methane Budgets with Copernicus Land Water and Wetness Data to Detect Land Use-Related Emissions

Remote Sensing, 2023
Climate change mitigation requires countries to report their annual greenhouse gas (GHG) emissions and sinks, including those from land use, land use change, and forestry (LULUCF).
Maria K. Tenkanen, Aki Tsuruta, Vilna Tyystjärvi, Markus Törmä, Iida Autio, Markus Haakana, Tarja Tuomainen, Antti Leppänen, Tiina Markkanen, Maarit Raivonen, Sini Niinistö, Ali Nadir Arslan, Tuula Aalto   +12 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source