Results 91 to 100 of about 77,334 (297)

Synthesis of some natural sulphonamide derivatives as carbonic anhydrase inhibitors

, 2017
Carbonic anhydrase inhibitor; sulphonamides; p-hydroxybenzoic acid; 3,4,5-trihydroxybenzoic acid (gallic acid).Carbonic anhydrase inhibitors are both in clinical use as antiglaucoma, diuretics, antiepileptics and management of altitude sickness, and ...
Melike Al, Turan Ozturk, Ahmet C Goren, Topal, Meryem, Goren, Ahmet C., OZTURK, Turan, Meryem Topal, AL, Melike, Gokcen, Taner, GÜLÇİN, İlhami, İlhami Gulcin, Taner Gokcen   +11 more
core   +1 more source

Keeping It Native: Non‐Denaturing Approaches to Top‐Down Protein Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics and top‐down mass spectrometry approaches provide direct characterization of proteoforms; the specific molecular forms of proteins, including post‐translational modifications, truncations, alternative splicing, and sequence variants.
Michael Xiao, Edvaldo Vasconcelos Soares Maciel, Frederik Lermyte, Owen S. Skinner   +3 more
wiley   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

The interaction of inhibitors with carbonic anhydrase

, 1991
The binding of several inhibitors to the metal site of carbonic anhydrase has been investigated through multinuclear ...
I. Bertini, SOLA, Marco, C. Luchinat, L. Banci   +3 more
core  

Photo‐responsive carbon dots for pyroptosis‐mediated anti‐tumor application

Responsive Materials, EarlyView.
Photo‐responsive CDs generate ROS to induce tumor cell pyroptosis, thereby stimulating antitumor immunity. Abstract Pyroptosis refers to a kind of lytic programmed cell death, characterized by the release of pro‐inflammatory cytokines during the process. Owing to its immune response stimulation ability, pyroptosis has garnered considerable attention in
Lingyun Li, Xue Wu, Zekun Yan, Jun Wu, Caishi Huang, Songnan Qu   +5 more
wiley   +1 more source

CARBONIC ANHYDRASE IN GREEN PLANTS

, 1950
Carbonic anhydrase was found in leaf extracts prepared from 19 of 22 land and aquatic plant species examined. The most active preparations were obtained from Spinacia oleracea L., Tetragonia expansa Thunb., Tropaeolum majus L., and Sambucus canadensis L.
K. A. Clendenning, E. R. Waygood
core   +1 more source

A Cytoplasmic pH Sensor Redefines Gating in Bacterial Urea Channels and Acid Resistance

Small, EarlyView.
Bacterial survival in acidic environments requires pH‐gated urea channels. Utilizing complementary approaches, we identify a conserved cytoplasmic glutamic acid residue as a pH sensor in UreI channels. Whereas Gram‐positive bacteria rely solely on this sensor, Gram‐negative bacteria employ a dual‐sensor mechanism with periplasmic residues, revealing a ...
Anna Stoib, Sahar Shojaei, Xenia Fischer, Sandra Posch, Gianluca Parisse, Mario Frezzini, Tobias Putz, Christine Siligan, Nikolaus Goessweiner‐Mohr, Daniele Narzi, Andreas Horner   +10 more
wiley   +1 more source

Stereochemistry matters: Inhibition of carbonic anhydrase II by amino acid derived sulfamates depends on their absolute configuration

European Journal of Medicinal Chemistry Reports
Aminoalcohols were converted into the corresponding enantiomeric phenylsulfonamide sulfamates. These compounds proved to be inhibitors of carbonic anhydrase II.
Toni C. Denner, Elsa L. Klett, Niels V. Heise, René Csuk   +3 more
doaj   +1 more source

Metal Poison Inhibition of Carbonic Anhydrase.

, 1993
A commentary is offered on the determination of the binding mode of cyanide and cyanate ions to the zinc atom of carbonic ...
SOLA, Marco
core   +1 more source

Designable Nanozymes for Site‐Selective Amide/Ester Hydrolysis

Small, EarlyView.
Enzymes involved in posttranslational modifications of proteins routinely perform site‐selective catalysis, regardless of the intrinsic reactivities of the myriad of functional groups present. Synthetic mimics of these enzymes are created through molecular imprinting, with catalytic groups positioned precisely near the targeted amide or ester bonds ...
Shashank Singh, Rasmita Barik, Yan Zhao
wiley   +1 more source