Results 111 to 120 of about 63,059 (304)

Plasma PlGF as a Potential Biomarker in Ramucirumab‐Based Second‐Line Therapy for Advanced Gastroesophageal Adenocarcinoma: Exploratory Biomarker Analysis from the Phase II Part of the RAMIRIS Trial

International Journal of Cancer, EarlyView.
Antiangiogenic treatment with ramucirumab is a standard second‐line option in advanced gastric and gastroesophageal junction adenocarcinoma. However, reliable biomarkers are currently lacking. This exploratory biomarker analysis of the RAMIRIS trial suggests that elevated baseline and early on‐treatment levels of the pro‐angiogenic placental growth ...
Jurek Hille, Sylvie Lorenzen, Claudia Pauligk, Victoria Gensch, Peter Thuss‐Patience, Eray Goekkurt, Thomas Ettrich, Florian Lordick, Carsten Bokemeyer, Christian Müller, Peter Reichardt, Martin Sökler, Daniel Pink, Stefan Probst, Thorsten O. Goetze, Salah E. Al‐Batran, Sonja Loges, Melanie Janning   +17 more
wiley   +1 more source

Optimizing feather hydrolysate via machine learning for microbial recycling of waste concrete fines

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The concrete industry faces significant challenges from CO2 emissions and the disposal of waste concrete fines (WCF). Microbially induced calcite precipitation (MICP) can bind WCF into bioconcrete, but the high cost of commercial culture media hinders its application.
Henrietta Ottová, Barbora Malíková, Václav Nežerka, Petr Holeček, Dana Koňáková, Hana Stiborová   +5 more
wiley   +1 more source

Anticancer evaluation of Myo-inositol through carbonic anhydrase IV inhibition activity: A spectroscopic, quantum computational, topological, drug-likeness and in-silico molecular docking studies

Results in Chemistry
Numerous inositol isomers, particularly myo-inositol, are beneficial in the treatment of polycystic ovary syndrome, diabetes, anxiety, and depression. This study established that myo-inositol has the potential to be utilized as a carbonic anhydrase IV ...
K. Rajkumar, V. Gokulakrishnan, S. Anand, R. Durga, G. Senthilkumar, S. Sri Karthick, R. Kayalvizhi Kothai   +6 more
doaj   +1 more source

Natural products that inhibit carbonic anhydrase

, 2013
Full ...
Rohan A. Davis, Davis, Rohan A, Sally-Ann Poulsen, Poulsen, Sally-Ann, Davis, Rohan   +4 more
core   +1 more source

Diagnostic modulation of subgingival proteomic biomarkers by age and smoking habits in periodontitis

Journal of Periodontology, EarlyView.
Abstract Background Although age and smoking influence the periodontal proteome, their impact on subgingival biomarkers for diagnosing periodontitis remains unclear. This multicenter study assessed their influence on subgingival proteins for disease detection.
Triana Blanco‐Pintos, Alba Regueira‐Iglesias, Berta Suárez‐Rodríguez, Alba Sánchez‐Barco, Iryna Kuz, Marta Relvas, Susana Belén Bravo, Carlos Balsa‐Castro, Inmaculada Tomás   +8 more
wiley   +1 more source

Structure-based drug design of novel inhibitors of carbonic anhydrase for treatment of glaucoma

, 2009
In humans, there are twelve carbonic anhydrase (CA) isozymes that possess catalytic activity for the reversible hydration of carbon dioxide. Carbonic anhydrases (CAs) underpin crucial physiological and pathological processes and are thus pharmaceutical ...
Singer, Mathilde, Hofmann, Andreas, Lopez, Marie, Paul, Blessy, Poulsen, Sally-Ann   +4 more
core  

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Synthesis of some natural sulphonamide derivatives as carbonic anhydrase inhibitors

, 2017
Carbonic anhydrase inhibitor; sulphonamides; p-hydroxybenzoic acid; 3,4,5-trihydroxybenzoic acid (gallic acid).Carbonic anhydrase inhibitors are both in clinical use as antiglaucoma, diuretics, antiepileptics and management of altitude sickness, and ...
Melike Al, Turan Ozturk, Ahmet C Goren, Topal, Meryem, Goren, Ahmet C., OZTURK, Turan, Meryem Topal, AL, Melike, Gokcen, Taner, GÜLÇİN, İlhami, İlhami Gulcin, Taner Gokcen   +11 more
core   +1 more source

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source

Immunohistochemical expression and association of hypoxia-inducible factor 1a and carbonic anhydrase IX in colorectal cancer

The presented work focuses on hypoxia-inducible factor 1a (HIF-1a) and carbonic anhydrase IX (CA IX) in colorectal cancer (CRC). The HIF-1a protein shows increased expression due to hypoxia, resulting in up-regulation of CA IX, which is involved in the ...
Veronika Mešťanová, Marian Adamkov, Veronika Cígerová, Marián Grendár   +3 more
core   +1 more source