Results 121 to 130 of about 75,270 (295)

Pharmacological inhibition of carbonic anhydrases with a positively charged pyridinium sulfonamide phenocopies the neuroprotective effects of Car9 genetic ablation in a murine setting of oxygen/glucose deprivation followed by re-oxygenation and is associated with improved neuronal function in ischemic rats

Heliyon
Carbonic anhydrases constitute a family of metalloenzymes vital for maintaining acid-base balance and regulating pH in physio-pathological processes. These findings suggest carbonic anhydrases as potential therapeutic targets for treating pH-associated ...
Sara Amiranda, Mariangela Succoio, Serenella Anzilotti, Ornella Cuomo, Tiziana Petrozziello, Valentina Tedeschi, Arianna Finizio, Giorgia Mele, Seppo Parkkila, Lucio Annunziato, Giuseppina De Simone, Giuseppe Pignataro, Agnese Secondo, Nicola Zambrano   +13 more
doaj   +1 more source

Structural study of the Carbonic Anhydrase SazCA from the thermophilic bacterium Sulfurihydrogenibium Azorense

, 2015
Purpose and Objective: ?-Carbonic anhydrases (?-CAs) are zinc-enzymes, which catalyze the reversible hydration of carbon dioxide to a bicarbonate ion and proton.
Giuseppina De Simone, Anna Di Fiore, Mosè Rossi, Vincenzo Alterio, Clemente Capasso, Viviana De Luca, Simona M Monti, Claudiu TSupuran, Katia D'Ambrosio, Vincenzo Carginale, Martina Buonanno   +10 more
core  

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

CARBONIC ANHYDRASE

Journal of Biological Chemistry, 1942
D. A. SCOTT, A. M. FISHER
openaire   +1 more source

Increased oxidation-related glutathionylation and carbonic anhydrase activity in endometriosis.

, 2014
This study examined the possible involvement of carbonic anhydrase activation in response to an endometriosis-related increase in oxidative stress. Peripheral blood samples obtained from 27 healthy controls and 30 endometriosis patients, classified as ...
DONA', GABRIELLA, CLARI, GIULIO, ARMANINI, DECIO, BRUNATI, ANNA MARIA, AMBROSINI, GUIDO, RAGAZZI, EUGENIO, ANDRISANI, ALESSANDRA, BORDIN, LUCIANA   +7 more
core   +1 more source

Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments

Smart Molecules, EarlyView.
Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu, Jiaxuan Zhu, Lei Lei, Qingyang Zhong, Zhao Li, Caihong Lei, Fan Rong, Yin Wang   +7 more
wiley   +1 more source

Evaluation of systemic consequences of brachycephalic obstructive airway syndrome in dogs

Veterinary Record, EarlyView.
Abstract Background Brachycephalic obstructive airway syndrome (BOAS) results from upper airway anatomical abnormalities and may cause systemic effects depending on severity. Methods A prospective, case‒control and observational study was conducted.
Andréia Coutinho Facin, Ariadne Rein, Isabella de Almeida Fabris, Beatriz Gasser, Luiz Paulo Nogueira Aires, Bruna Bressianini Lima, Daniele Azevedo Gandra, Daniela Gomes da Silva, Ricardo Andrés Ramirez Uscategui, Gabriela Castro Lopes Evangelista, Marcus Antônio Rossi Feliciano, Paola Castro Moraes   +11 more
wiley   +1 more source

(Z)-N-(3-([1,1'-biphenyl]-2-yl)-4-heptyl-4-hydroxythiazolidin-2-ylidene)-4-bromobenzamide as carbonic anhydrase inhibitor: exploration of its in vitro and in silico studies

BMC Chemistry
Human Carbonic Anhydrase inhibitors (CAIs) have been clinically used to treat a variety of disorders, such as cancer, obesity, haemolytic anaemia, glaucoma, retinopathy, and epilepsy.
Aftab Ahmed, Sara Ilyas, Pervaiz Ali Channar, Syeda Abida Ejaz, Aamer Saeed, Seema Sarwar Ghumro, Mohamad Ahmad Saleem Khasawneh, Shagufta Naz Channar, Rabail Ujan, Qamar Abbas, Tuncer Hökelek   +10 more
doaj   +1 more source

The BioSAXS laboratory of the ITACA.SB Research Infrastructure

Journal of Applied Crystallography, EarlyView.
We present a versatile state‐of‐the‐art X‐ray scattering laboratory within the ITACA.SB Research Infrastructure, enabling multi‐scale structural characterization of complex biological specimens and advanced materials through integrated small‐ and wide‐angle X‐ray scattering (SAXS/WAXS) techniques.
Francesco Scattarella, Davide Altamura, Vincenzo Mangini, Teresa Sibillano, Erika Manicone, Rocco Lassandro, Liberato De Caro, Gemma Newby, Cinzia Giannini   +8 more
wiley   +1 more source

Microarrayed Allergen Molecules Distinguish IgE Sensitisation to Blomia tropicalis and Dermatophagoides pteronyssinus

Allergy, EarlyView.
This study established a microarray containing a representative panel of purified Blo t and Der p allergens for the identification of patients sensitised to Blo t and/or Der p. Results indicate that the microarray based on Blo t and Der p allergens is a useful tool for the identification of Blo t‐ and/or Der p‐sensitised patients. The microarray may be
Nishelle Dsouza, Siratcha Phanthong, Huey‐Jy Huang, Milena Weber, Eszter Sarzsinszky, Petra Zieglmayer, Gabrielle Pauli, Margarete Focke‐Tejkl, Mikhail Tulaev, Nikolina Todorovic, Walter Keller, Thomas Schlederer, Luis Caraballo, Anchalee Tungtrongchitr, Rudolf Valenta, Pongsakorn Tantilipikorn, Susanne Vrtala   +16 more
wiley   +1 more source