Results 241 to 250 of about 2,453,486 (333)

In Vitro Leishmanicidal Efficacy of Synthesized Arylidene Analogues of Glitazone

open access: yesDrug Development Research, Volume 86, Issue 5, August 2025.
ABSTRACT Diabetes is a fast‐growing health issue in low‐ and middle‐income countries, with ~80% of diabetics living in the tropics and sub‐tropics. It is a deadly condition claiming the lives of millions of individuals annually, with no therapeutic treatment available to date. The management of diabetes is thus limited to symptomatic relief by glycemic
Janine Aucamp   +4 more
wiley   +1 more source

GEO combined with quantitative protein trait loci identify causative proteins in hypertrophic cardiomyopathy

open access: yesESC Heart Failure, Volume 12, Issue 4, Page 2827-2833, August 2025.
Abstract Aims Hypertrophic cardiomyopathy (HCM) is a rare genetic heart disease characterized by a limited patient population and scarce research and treatment resources. This study aimed to identify HCM‐associated proteins by integrating cardiac tissue data from the Gene Expression Omnibus (GEO) database with the latest protein quantitative trait ...
Bo Li, Xu Zhao, Yan Ding, Yi Zhang
wiley   +1 more source

Improved Annotation of Internal Fragments via Trapped‐Ion Mobility Enhanced Top‐Down Sequencing of Protein Ions

open access: yesJournal of Mass Spectrometry, Volume 60, Issue 8, August 2025.
ABSTRACT Analysis of intact protein ions allows for valuable insights into complex biological processes. However, top‐down mass spectrometry data is often convoluted and frequently results in numerous overlapping product ions. Ion mobility spectrometry (IMS) can aid in the deconvolution of these spectra, and we previously demonstrated that the IMS ...
Katherine A. Graham   +7 more
wiley   +1 more source

Highly Active Carbonic Anhydrase of the Thylakoid Lumen of Chlamydomonas reinhardtii. [PDF]

open access: yesPlants (Basel)
Terentyev VV   +4 more
europepmc   +1 more source

Breathing and balance: Clinical insights and management strategies of respiratory acid‐base disorders

open access: yesNutrition in Clinical Practice, Volume 40, Issue 4, Page 774-792, August 2025.
Abstract Respiratory acidosis and alkalosis are two of the four main acid‐base processes encountered in clinical practice. These two processes are tightly balanced by breathing. Identification and management of respiratory acid‐base disorders are important for clinicians, particularly when caring for patients with underlying pulmonary and neurological ...
Anne M. Tucker, Tami N. Johnson
wiley   +1 more source

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