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Carbonic Anhydrase Inhibitors as Anticonvulsant Agents
Current Topics in Medicinal Chemistry, 2007Seizures are one of the most common neurological disorders in clinical medicine. Triggering mechanisms by which seizures form remain unclear, but are related to a rapid change in ionic composition, including an increase of intracellular potassium concentration and pH shifts within the brain.
A. Thiry +3 more
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Safety of carbonic anhydrase inhibitors
Expert Opinion on Drug Safety, 2014Carbonic anhydrase (CA) inhibitors have an impressive safety record despite the multiple functions that CA isozymes serve because they are not fully inhibited with most dosing. While reducing the targeted CA-dependent process sufficiently for disease control, residual activity and uncatalyzed rates in combination with compensations are adequate to ...
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Nature, 1967
CARBONIC anhydrase is present in the frog gastric mucosa and fish gill which actively transport chloride, and it has been observed that carbonic anhydrase inhibitors of the sulphonamide type decrease net chloride active transport in these tissues1,2. Zadunaisky3 has reported that chloride is actively transported by the frog cornea, and 95–100 per cent ...
S, Kitahara, K R, Fox, C A, Hogben
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CARBONIC anhydrase is present in the frog gastric mucosa and fish gill which actively transport chloride, and it has been observed that carbonic anhydrase inhibitors of the sulphonamide type decrease net chloride active transport in these tissues1,2. Zadunaisky3 has reported that chloride is actively transported by the frog cornea, and 95–100 per cent ...
S, Kitahara, K R, Fox, C A, Hogben
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Patient Tolerance to Carbonic Anhydrase Inhibitors
American Journal of Ophthalmology, 1978We evaluated carbonic anhydrase inhibitors in a crossover study with a placebo and random allocation of treatment administration. Drugs evaluated included acetazolamide tablets and Sequels, dichlorphenamide, ethoxzolamide, methazolamide, and an ascorbic acid placebo. The best tolerated drug was acetazolamide Sequels. Methazolamide was next.
P R, Lichter +3 more
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1985
Inhibitors of carbonic anhydrase presently have a limited role in the treatment of epilepsy. Inorganic anions, such as I−, CN−, SH−, CNO−, SCN−, and Br−, and sulfonamides are inhibitors of the enzyme carbonic anhydrase (Maren 1967). Both bromides and sulfonamides have been used in the treatment of epilepsy in man.
J. E. Riggs, R. C. Griggs
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Inhibitors of carbonic anhydrase presently have a limited role in the treatment of epilepsy. Inorganic anions, such as I−, CN−, SH−, CNO−, SCN−, and Br−, and sulfonamides are inhibitors of the enzyme carbonic anhydrase (Maren 1967). Both bromides and sulfonamides have been used in the treatment of epilepsy in man.
J. E. Riggs, R. C. Griggs
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A carbonic anhydrase inhibitor as a diuretic in obstetrics
American Journal of Obstetrics and Gynecology, 1958Abstract Our inadequate knowledge concerning the etiology of toxemia of pregnancy has led us to treat this clinical entity empirically. Eclamptic convulsions are managed by sedation or parenteral magnesium sulfate. Hypertension is treated by sedation and hypotensive drugs.
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Boron-containing carbonic anhydrases inhibitors
Bioorganic ChemistryOver the last decades, the medicinal chemistry of boron-based compounds has been extensively explored, designing valuable small molecule drugs to tackle diseases and conditions, such as cancer, infections, inflammatory and neurological disorders.
Giovannuzzi, Simone +6 more
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Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors
European Journal of Medicinal Chemistry, 2021Vikramdeep Monga, Shalini Jaswal
exaly