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Carbonic Anhydrase Inhibitors as Anticonvulsant Agents
Current Topics in Medicinal Chemistry, 2007Seizures are one of the most common neurological disorders in clinical medicine. Triggering mechanisms by which seizures form remain unclear, but are related to a rapid change in ionic composition, including an increase of intracellular potassium concentration and pH shifts within the brain.
A. Thiry +3 more
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Nature, 1967
CARBONIC anhydrase is present in the frog gastric mucosa and fish gill which actively transport chloride, and it has been observed that carbonic anhydrase inhibitors of the sulphonamide type decrease net chloride active transport in these tissues1,2. Zadunaisky3 has reported that chloride is actively transported by the frog cornea, and 95–100 per cent ...
S, Kitahara, K R, Fox, C A, Hogben
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CARBONIC anhydrase is present in the frog gastric mucosa and fish gill which actively transport chloride, and it has been observed that carbonic anhydrase inhibitors of the sulphonamide type decrease net chloride active transport in these tissues1,2. Zadunaisky3 has reported that chloride is actively transported by the frog cornea, and 95–100 per cent ...
S, Kitahara, K R, Fox, C A, Hogben
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Patient Tolerance to Carbonic Anhydrase Inhibitors
American Journal of Ophthalmology, 1978We evaluated carbonic anhydrase inhibitors in a crossover study with a placebo and random allocation of treatment administration. Drugs evaluated included acetazolamide tablets and Sequels, dichlorphenamide, ethoxzolamide, methazolamide, and an ascorbic acid placebo. The best tolerated drug was acetazolamide Sequels. Methazolamide was next.
P R, Lichter +3 more
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Carbonic anhydrase inhibitor in trout plasma
Respiration Physiology, 1976A manometric assay has been constructed such that carbonic anhydrase dehydration activity can be determined utilizing intact erythrocytes. It was found that unwashed whole trout blood lacks any dehydration activity quite in contrast to whole rat blood.
M S, Haswell, D J, Randall
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Antiepileptic property of inhibitors of carbonic anhydrase
Biochemical Pharmacology, 1965Abstract Mechanism of the anticonvulsant action of the inhibitors of carbonic anhydrase was investigated in rats treated with an intraperitoneal or intraventricular injection of the drugs. The duration of the maximal electroshock seizure was taken as an indicator of the intensity of convulsions, and the activity of carbonic anhydrase in the brain and
H, Tanimukai +3 more
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Glaucoma and the Applications of Carbonic Anhydrase Inhibitors
2013Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) has pharmacologic applications in the treatment of glaucoma, a disease affecting a large number of people and characterized by an elevated intraocular pressure (IOP). At least three isoforms, CA II, IV and XII are targeted by the sulfonamide inhibitors, some of which are clinically used drugs ...
SCOZZAFAVA, ANDREA +1 more
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1985
Inhibitors of carbonic anhydrase presently have a limited role in the treatment of epilepsy. Inorganic anions, such as I−, CN−, SH−, CNO−, SCN−, and Br−, and sulfonamides are inhibitors of the enzyme carbonic anhydrase (Maren 1967). Both bromides and sulfonamides have been used in the treatment of epilepsy in man.
J. E. Riggs, R. C. Griggs
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Inhibitors of carbonic anhydrase presently have a limited role in the treatment of epilepsy. Inorganic anions, such as I−, CN−, SH−, CNO−, SCN−, and Br−, and sulfonamides are inhibitors of the enzyme carbonic anhydrase (Maren 1967). Both bromides and sulfonamides have been used in the treatment of epilepsy in man.
J. E. Riggs, R. C. Griggs
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Carbonic Anhydrase Inhibitors Drug Design
2013Inhibition of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) has pharmacologic applications in the field of antiglaucoma, anticonvulsant, antiobesity, and anticancer agents but is also emerging for designing anti-infectives (antifungal and antibacterial agents) with a novel mechanism of action. As a consequence, the drug design of CA inhibitors (
Robert, McKenna, Claudiu T, Supuran
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A carbonic anhydrase inhibitor as a diuretic in obstetrics
American Journal of Obstetrics and Gynecology, 1958Abstract Our inadequate knowledge concerning the etiology of toxemia of pregnancy has led us to treat this clinical entity empirically. Eclamptic convulsions are managed by sedation or parenteral magnesium sulfate. Hypertension is treated by sedation and hypotensive drugs.
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