Results 101 to 110 of about 41,221 (304)
Targeting Tumor-Associated Carbonic Anhydrases in Photothermal Therapy. [PDF]
ChemMedChemTumor‐associated carbonic anhydrases hCA IX and hCA XII, are overexpressed in hypoxic tumor regions and promote cancer cell survival. Targeting these enzymes enhances the efficacy of photothermal therapy (PTT), which uses NIR light for localized heat and apoptosis, representing a promising approach for cancer treatment.
Clément S, Richeter S, Winum JY.
europepmc +2 more sources
Cytoskeleton, EarlyView.ABSTRACT Cdt1 is a mixed folded protein critical for DNA replication licensing and it also has a “moonlighting” role at the kinetochore via direct binding to microtubules and the Ndc80 complex. However, it is unknown how the structure and conformations of Cdt1 could allow it to participate in these multiple, unique sets of protein complexes.
Kyle P. Smith +9 more
wiley +1 more source
4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases
Molecules, 2014 A series of N-aryl-β-alanine derivatives and diazobenzenesulfonamides containing aliphatic rings were designed, synthesized, and their binding to carbonic anhydrases (CA) I, II, VI, VII, XII, and XIII was studied by the fluorescent thermal shift assay ...
Kęstutis Rutkauskas +12 more
doaj +1 more source
Continuous Titration Based Method for Rapid In‐Solution Analysis of Non‐Covalent Interactions
Chemistry–Methods, EarlyView.This work presents cSPRING, which combines Taylor dispersion with ratiometric fluorescence detection to measure binding affinities (Kd) in a single experiment. This in‐solution method reduces sample preparation time 8‐fold, requires only nanograms of protein, and provides results in under a minute, demonstrating efficiency for screening protein‐small ...
Philipp Willmer +3 more
wiley +1 more source
Drug Testing and Analysis, EarlyView.Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario Thevis +2 more
wiley +1 more source
Global Change Biology, Volume 29, Issue 2, Page 505-521, January 2023., 2023 Our study investigated how photosynthesis and its components acclimate to drought stress (DS) and growth temperature (Tgrowth) in wheat, and examined to what extent ignoring these acclimations would lead to errors in predicting photosynthesis. We found that both diffusional and biochemical parameters of photosynthesis and their thermal sensitivity ...
Liang Fang +6 more
wiley +1 more source
Ketogenic diet therapy for the treatment of pediatric epilepsy
Epileptic Disorders, EarlyView.Abstract In 1921, the classic ketogenic diet was created at the Mayo Clinic in Rochester, Minnesota to treat epilepsy in children and adults. Over a century later, it is a widely used, standard‐of‐care therapy for typically treatment‐resistant epilepsy worldwide.
Babitha Haridas +2 more
wiley +1 more source
Journal of Internal Medicine, Volume 293, Issue 1, Page 4-22, January 2023., 2023 Abstract The kidneys, by equilibrating the outputs to the inputs, are essential for maintaining the constant volume, pH, and electrolyte composition of the internal milieu. Inability to do so, either because of internal kidney dysfunction (primary alteration) or because of some external factors (secondary alteration), leads to pathologies of varying ...
Nahid Tabibzadeh, Gilles Crambert
wiley +1 more source
Frontiers in Oncology, 2013 The relationship between acidosis within the tumor microenvironment and radioresistance of hypoxic tumor cells remains unclear. Previously we reported that hypoxia-induced carbonic anhydrases CAIX and CAXII constitute a robust pHi-regulating system that ...
Jérôme eDoyen +5 more
doaj +1 more source
Carbonic anhydrase. Its preparation and properties [PDF]
, 1933 Norman Urquhart Meldrum +1 more
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