Results 101 to 110 of about 27,386 (335)

Carbonic Anhydrases: Role in pH Control and Cancer

Metabolites, 2018
The pH of the tumor microenvironment drives the metastatic phenotype and chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH-dependent phenomenon will lead to improved drug delivery and allow the identification of new ...
Mam Y. Mboge, Brian P. Mahon, Robert McKenna, Susan C. Frost   +3 more
doaj   +1 more source

The Effect of Nanoparticles on the Structure and Enzymatic Activity of Human Carbonic Anhydrase I and II

Molecules, 2020
Human carbonic anhydrases (hCAs) belong to a well characterized group of metalloenzymes that catalyze the conversion of carbonic dioxide into bicarbonate.
Celia Cabaleiro-Lago, Martin Lundqvist
doaj   +1 more source

Synthesis, Characterization, Biological Properties, and Sensor Applications of Novel Thiosemicarbazone Derivatives

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT In this study, novel thiosemicarbazone derivative molecules (5a–j) were synthesized. The characterization of the synthesized molecules was carried out using 1H–, 13C–NMR, FT–IR, and Q–TOF spectroscopic techniques. Then, the inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and ...
Hayreddin Gezegen, Oguz Özbek, Meryem Topal, Hatice Şahin, Ümit M. Koçyiğit   +4 more
wiley   +1 more source

Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Pursuing on our efforts toward searching for efficient hCA IX and hCA XII inhibitors, herein we report the design and synthesis of new sets of benzofuran-based sulphonamides (4a,b, 5a,b, 9a–c, and 10a–d), featuring the zinc anchoring benzenesulfonamide ...
Mohamed A. Abdelrahman, Wagdy M. Eldehna, Alessio Nocentini, Hany S. Ibrahim, Hadia Almahli, Hatem A. Abdel-Aziz, Sahar M. Abou-Seri, Claudiu T. Supuran   +7 more
doaj   +1 more source

Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures [PDF]

, 2013
Peer ...
Blaesse, Peter, El Muayed, Malek, Helmy, Mohamed, Hennings, J. Christopher, Huebner, Antje K., Hübner, Christian A., Kaila, Kai, Kang, Hyo Jung, Kirilkin, Ilya, Ruusuvuori, Eva, Sestan, Nenad, Voipio, Juha, Yukin, Alexey Y.   +12 more
core   +2 more sources

Adaptive and Biochemical Responses of Dictyosphaerium sp. AM‐2024a to Environmental Conditions and Microplastic Interactions: Synergy of Biofuel Production With Pollution Mitigation

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT This study investigates the physiological and biochemical responses of a newly isolated microalgal strain, Dictyosphaerium sp. AM‐2024a, identified through 18S rDNA sequencing, under varying environmental conditions and microplastic (MP) interactions.
Khushboo Iqbal, Arti Mishra, Smitha Mony Sreedharan   +2 more
wiley   +1 more source

The prognostic value of the hypoxia markers CA IX and GLUT 1 and the cytokines VEGF and IL 6 in head and neck squamous cell carcinoma treated by radiotherapy ± chemotherapy [PDF]

, 2005
BACKGROUND: Several parameters of the tumor microenvironment, such as hypoxia, inflammation and angiogenesis, play a critical role in tumor aggressiveness and treatment response.
A Dietz, CC Wykoff, DM Brizel, E Tartour, EP Hui, Erik Verbeken, H Mineta, Harlinde De Schutter, J Bussink, J Dunst, JA Forsythe, JH Kaanders, K Muraoka, Laurence Goethals, M Kunkel, M Nordsmark, MA St John, MI Koukourakis, P Mellanen, P Vaupel, R Airley, R Hermans, R Srivani, Robert Hermans, S Ivanov, S Pastorekova, Sandra Nuyts, T Tamatani, TN Teknos, V Brouazin-Jousseaume, V Michalaki, W Jelkmann, Willy Landuyt, Y Miyamoto, YC Chung, Z Chen   +35 more
core   +3 more sources

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Comparison between alpha- and beta-carbonic anhydrases: can Zn(His)3(H2O) and Zn(His)(Cys)2(H2O) sites lead to equivalent enzymes?

, 2011
International audienceLarge models of alpha- and beta-carbonic anhydrases were compared using DFT calculations. They indicate similar acidity of coordinated water molecule and zinc affinity.
Frison, Gilles, Ohanessian, Gilles, Pannetier, Florent   +2 more
core   +3 more sources

Scalable production and biophysical characterization of an enzyme cocktail derived from human red blood cells

Biotechnology Progress, EarlyView.
Abstract Red blood cells (RBCs) play a critical role in oxygen and carbon dioxide transport, which is facilitated by RBC‐encapsulated hemoglobin (Hb) and carbonic anhydrase (CA). In addition, RBCs are constantly exposed to oxidative stress due to the intracellular reactive oxygen species (ROS) generated during Hb auto‐oxidation.
Mohd Asim Khan, Griffin J. Beyer, Naomi Goosby, Lilly Ortiz, Andre F. Palmer   +4 more
wiley   +1 more source