Results 201 to 210 of about 2,925,002 (305)

De Novo Discovery of Bioactive Cyclic Peptides via Cellular Selection of Genetically Encoded Libraries

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
Genetically encoded cyclic peptide libraries can be employed in cellular selection platforms to identify cyclic peptide inhibitors for therapeutic targets by directly selecting for desired biological activities. This review systematically summarizes representative studies and suggests future opportunities for using cellular selection for de novo cyclic
Linwei Yang, Abhijit Behera, Hannah J. Meyers, Tina Wang   +3 more
wiley   +1 more source

Hybridization Approach Applied to Umbelliferon and Vanilloids toward New Inhibitors of Carbonic Anhydrases IX and XII with In Vitro Antiproliferative and Anti-inflammatory Activities. [PDF]

J Med Chem
Melfi F, Mencarelli N, Carradori S, Gallorini M, Angeli A, Poli G, Cataldi A, D'Agostino I, Di Credico A, Di Baldassarre A, Tuccinardi T, Supuran CT.   +11 more
europepmc   +1 more source

Synthesis and In Vivo Incorporation of 4‐Difluoromethyl‐L‐Phenylalanine Into Proteins

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
The amino acid 4‐difluoromethyl‐L‐phenylalanine was synthesized and incorporated into full‐length proteins using an orthogonal aminoacyl‐tRNA synthetase (aaRS) with standard genetic code expansion techniques. Subsequent experiments with these proteins show the application of the difluoromethyl group in 19F NMR‐based protein structure studies.
Daniel S. Honeycutt, Jason M. Mrosla, Sarah A. Sexton, Giovanni E. Cavalli, Emmerson G. Bartels, Brian Pallares, William K. McCarthy, Ruojun Wu, Fang Wang, Jacob M. Goldberg   +9 more
wiley   +1 more source

Structural, nonlinear optical, and molecular docking studies of schiff base compounds as multi-target inhibitors of AChE, BChE, and carbonic anhydrases. [PDF]

Sci Rep
Kourat O, Benhalima N, Al-Dies AM, Guendouzi A, Benyahlou ZD, Megrouss Y, Drissi M, Alem GA, Sindi ER, Zaki MEA.   +9 more
europepmc   +1 more source

Synthesis and Evaluation of Thiazolidinone-Isatin Hybrids for Selective Inhibition of Cancer-Related Carbonic Anhydrases. [PDF]

ACS Med Chem Lett
Onali A, Sanna E, Lupia A, Secci D, Atzeni G, Demuru L, Angeli A, Cottiglia F, Meleddu R, Emmolo R, Corona A, Maccioni E, Supuran CT, Distinto S.   +13 more
europepmc   +1 more source

The catalytic mechanism of mammalian carbonic anhydrases

, 2000
Silverman, D N, Lindskog, Sven,
core  

Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release

Chemistry – A European Journal, Volume 32, Issue 35, 19 September 2026.
Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka, Marek Chovanec, Rastislav Dzijak, Michal Rahm, Jachym Hrusak, Paul E. Reyes‐Gutierrez, Milan Vrabel   +6 more
wiley   +1 more source

RETRACTED: Sarnella et al. A Novel Inhibitor of Carbonic Anhydrases Prevents Hypoxia-Induced TNBC Cell Plasticity. <i>Int. J. Mol. Sci.</i> 2020, <i>21</i>, 8405. [PDF]

Int J Mol Sci
Sarnella A, D'Avino G, Hill BS, Alterio V, Winum JY, Supuran CT, De Simone G, Zannetti A.   +7 more
europepmc   +1 more source

Bioinspired Zinc Macrocycles Confined in UiO‐67: A Heterogeneous Synzyme for Sustainable CO2 Valorization

ChemSusChem, Volume 19, Issue 17, 14 September 2026.
By mimicking nature’s use of weak supramolecular interactions, zinc macrocycles are assembled within defective UiO‐67 to create cooperative synzymes for CO2 valorization. Confined amines, hydrogen‐bonding networks and accessible iodides work in concert to activate CO2 and epoxides at ambient pressure, delivering additive‐free catalysis that outperforms
J. E. Chiva, J. E. Sánchez‐Velandia, F. Esteve, F. G. Cirujano, C. Vicent, N. Martín, B. Altava, E. García‐Verdugo   +7 more
wiley   +1 more source

Synergistic roles of aquaporin 5 and intra- and extracellular carbonic anhydrases in promoting CO₂ diffusion across the Xenopus oocyte plasma membrane. [PDF]

J Physiol
Wang DK, Moss FJ, Boron WF.
europepmc   +1 more source