Results 51 to 60 of about 27,386 (335)

Cathepsin K in lymphangioleiomyomatosis: LAM cell-fibroblast Interactions enhance protease activity by extracellular acidification [PDF]

, 2017
Lymphangioleiomyomatosis (LAM) is a rare disease in which clonal ‘LAM’ cells infiltrate the lungs and lymphatics. In association with recruited fibroblasts, LAM cells form nodules adjacent to lung cysts. It is assumed LAM nodule derived proteases lead to
Akhenblit, Andrew J. Fisher, Arundhati Dongre, Atochina-Vasserman, Badri, Bee, Boonen, Bromme, Chang, Chang, Chilosi, Clements, Debbie Clements, Ferri, Finlay, Goldberg, Goncharova, Goncharova, Greenlee, Hayashi, Henske, Inoue, Johnson, Kaluz, Kang, Kant, Kneissel, Lecaille, Lee, Levy, Livak, Lou, Martignoni, Matsui, McCormack, McCormack, McDonald, McIntyre, Montgomery, Odajima, Onda, Pacchiano, Parkhitko, Pea, Punturieri, Repnik, Riihonen, Romero, Simon R. Johnson, Touisni, Turk, Yu, Zhao, Zhe   +53 more
core   +2 more sources

Sucrose rinse modulates the salivary behavior of carbonic anhydrase VI and its buffering capacity: a longitudinal study in 4 to 6.5-year-old children [PDF]

PeerJ
Background Carbonic anhydrase VI (CA VI) is crucial in regulating oral pH and predicting susceptibility to dental caries. The hypothesis posits that caries activity may alter the CA VI function, diminishing its capacity to regulate pH effectively and ...
Thayse Rodrigues de Souza, Bruna Raquel Zancope, Emerson Tavares de Sousa, Thais Manzano Parisotto, Marcelo Rocha Marques, Marinês Nobre dos Santos   +5 more
doaj   +2 more sources

Carbonic Anhydrase Inhibitors

Kidney and Blood Pressure Research, 1987
The purpose of the present review is to describe the use of carbonic anhydrase inhibitors in clinical medicine and renal physiology. We first describe the localization of carbonic anhydrase within the kidney and then discuss evidence for its role in renal acidification and NaCl absorption.
P A, Preisig, R D, Toto, R J, Alpern
openaire   +2 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Electrolyte and Water Balance of the Early Avian Embryo: Effects of Egg Turning [PDF]

, 2002
Formation of sub-embryonic fluid (SEF) is a key aspect of the physiology of the early avian embryo.Here we review the process of SEF formation and the factors which influence its composition and the rate of SEF production and depletion in the Japanese ...
Baggott, Glenn K., Deeming, D.C., Latter, G.V.   +2 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Activation of carbonic anhydrase isoforms involved in modulation of emotional memory and cognitive disorders with histamine agonists, antagonists and derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Carbonic anhydrases (CAs, EC 4.2.1.1) activators were shown to be involved in memory enhancement and learning in animal models of cognition. Here we investigated the CA activating effects of a large series of histamine based compounds, including ...
Gustavo Provensi, Alessio Nocentini, Maria Beatrice Passani, Patrizio Blandina, Claudiu T. Supuran   +4 more
doaj   +1 more source

Quantification of carbonic anhydrase gene expression in ventricle of hypertrophic and failing human heart [PDF]

, 2013
Background: Carbonic anhydrase enzymes (CA) catalyze the reversible hydration of carbon dioxide to bicarbonate in mammalian cells. Trans-membrane transport of CA-produced bicarbonate contributes significantly to cellular pH regulation. A body of evidence
Alvarez, Bernardo, Casey, Joseph R., Mullen, John, Quon, Anita L.   +3 more
core   +2 more sources

Diagnostic Utility of Testing for Novel Murine Autoantibodies for Sjögren's Disease in the Rheumatology Outpatient Setting

Arthritis Care &Research, Accepted Article.
Objective The goal was to assess the diagnostic performance of three novel autoantibodies (NA) for Sjögren's disease (SjD) by comparing NA prevalence in patients with SjD, other autoimmune rheumatic diseases (ARDs), nonspecific chronic sialadenitis (CS), and controls.
Chadwick R. Johr, Michael D. George, Vatinee Y. Bunya, Nora Sandorfi, Mina Massaro‐Giordano, Frederick B. Vivino   +5 more
wiley   +1 more source

Carbonic Anhydrase from Porphyromonas Gingivalis as a Drug Target

Pathogens, 2017
Periodontitis originates from a microbial synergy causing the development of a mouth microbial imbalance (dysbiosis), consisting of a microbial community composed of anaerobic bacteria.
Claudiu T. Supuran, Clemente Capasso
doaj   +1 more source