Results 51 to 60 of about 69,223 (345)
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
New data on Carboniferous plants of the Rostov-on-Don Region (Russia)
Vestnik MGTU, 2023 The paper contains a review of the higher plant fossils collected from the Middle Carboniferous deposits of two localities disposed in the Rostov-on-Don Region. The collection includes fossils of arborescent lycopodiopsids Lepidodendron cf.
Naugolnykh S. V., Linkevich V. V.
doaj +1 more source
Parsimonious numerical modelling of deep geothermal reservoirs [PDF]
, 2015 Numerical modelling has been undertaken to help improve understanding of a deep geothermal system being considered for development in the vicinity of Eastgate (Weardale, County Durham, UK).
Fairs, Tim H. +2 more
core +1 more source
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Geologica Acta, 2011 The magnetic properties of the Carboniferous-Permian red beds of the Patquía Formation at Punta del Viento, Sierra de Umango and some previously reported localities, all in the Paganzo Basin (Argentina), have been studied.
S.E. GEUNA +2 more
doaj
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
, 2013 Breedon Hill forms one of the most prominent features in the landscape of north-west Leicestershire, standing up 50 m above the surrounding ground. That it has been a major landmark throughout recorded history is suggested by its name, which is derived ...
Ambrose, Keith
core
Carboniferous and Permian magmatism in Scotland [PDF]
, 2004 Extensional tectonics to the north of the Variscan Front during the Early Carboniferous generated fault-controlled basins across the British Isles, with accompanying basaltic magmatism.
Fitton, J.G. +4 more
core +1 more source
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source